Proligo® Phosphoramidites and Reagents for Oligonucleotide Synthesis

The Proligo® reagents portfolio offers a full range of phosphoramidites, solid supports and liquid reagents for oligonucleotide synthesis that include the following features:

  • High quality standard and specialized products for the complete workflow
  • Flexible and customizable production and packaging options

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Synthesis Supports

Controlled Pore Glass (CPG) hasproven to be the most acceptedsupports for the chemical synthesisof DNA and RNA. Features includehigh surface area, efficient masstransfer and chemical inertness.

Controlled Pore Glass

Detritylation & Activation

Coupling takes place once theDMT groups are removed throughthe detritylation mechanismutilizing TCA.

Detritylation Products:

Deblock

Activator solutions are mixed withsolutions of phosphoramiditesduring the extension step. Theactivator reacts with the amiditegroup to form a highly reactiveintermediate. The intermediatethen forms an internucleotidebond with the detritylated 5′hydroxylgroup of the growing oligonucleotidechain.

Activation Product:

Activators

Coupling

Phosphoramidite monomers are added through the coupling mechanism utilizing the following products:

Coupling Products:

DNA Amidites
  (Standard and Fast Deprotection)
RNA Amidites
  (Standard and Fast Deprotection)
Linkers
Dyes and Label

Capping & Oxidation

Stabilization of the reactions andefficiency of the yield is achievedthrough oxidation and capping.

Capping Products:

Cap A
Cap B

Oxidization Products:

Oxidizers

 Capabilities and Services

 

Quality Assurance
Dedicated process technology group and in-process controls that will adapt to evolving diagnostic and pharmaceutical requirements.

 

 

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State-of-the-Art Production
Complete packaging services from routine to custom and from milligrams to kilograms at our state-of-the-Art Manufacturing facility in Hamburg.