Nucleic Acid Chemistry

Proligo® Manufacturing Site - Hamburg



State-of-the-Art Production
The Proligo® manufacturing site in Hamburg, Germany is designed as a multi-purpose facility with built-in flexibility and the capability to manufacture a complex mix of products to suit a variety of customer needs.

DNA and RNA phosphoramidites are manufactured in glass-lined reactors and purified by preparative column chromatography on silica gel with medium-to-high pressure chromatography equipment.

The Hamburg facility has the flexibility to prepare and purify alternative mixes of high volume standard products as well as small scale specialties.



Take a Tour of the Production Site

Click on the image to launch a virtual tour of our manufacturing facility.


Features Include:

  • Modern laboratories with state-of-the-art analytical support
  • Integrated solvent delivery
  • A strong background in speciality monomer manufacturing
  • CPG production using the Schott process
  • Extensive storage and warehousing facilities with worldwide distribution services


Preparative HPLC Purification

Phosphoramidites are purified at the Hamburg facility by preparative column chromatography on silica gel with medium to high pressure chromatography equipment.

Proligo is able to offer:

  • DCM handling capability
  • Integrated solvent delivery
  • >5000 kg/year amidite purification capacity
  • Three shift operation
  • Automated batch processing
  • State-of-the-art process visualisation
  • Built-in CIP procedures

World's Largest Amidite Manufacturer

Proligo offers reagents for the synthesis of oligonucleotides including phosphoramidites, solid supports and liquid formulations.

Annual amidite production capacity is more than five tons, to meet growing industry demands and ensure reliable supply.

Large-scale production facilities include:

  • Glass-lined reactors up to 1000 L
  • Multiple mid-size reactor systems from 20 to 200 L
  • Hazardous solvent and reagent handling
  • Integrated solvent delivery from tank farm

Address: Sigma-Aldrich, Hamburg, Germany