HyStem™ Cell Culture

What is Heparin?

Brief Summary
Heparan sulfate (HS) is a component of the extracellular matrix1,2. It is a glycosaminoglycan that is covalently attached to core proteins to form proteoglycans. Its structure is amazingly diverse since during synthesis it undergoes extensive sulfation and epimerization1. Heparin is distinct from HS in that it is produced primarily by mast cells, whereas, HS is produced by all cell types1. Note that there is not a single HS or heparin structure. Instead, the basic polysaccharide components that make up these molecules vary depending upon the tissue and the developmental stage.