Polyphosphoesters exhibit many properties necessary for drug delivery and gene delivery.
  • Structurally similar to nucleic and teichoic acids.
  • Biodegrade through hydrolysis and possibly enzymatic digestion.
  • One of the few classes of polymers for non-viral gene delivery by conjugation of charged groups to the side chain of the phosphate.

1. Zhan, Z. et. al. Adv. Drug Delv. Rev. 55, 483 (2003).
2. Penczek, S. et al. Polish J. Chem., 75, 1171 (2001).
3. Penczek, S. et al. Polish J. Chem., 68, 2129 (1994).

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659738 Poly[1,4-bis(hydroxyethyl)terephthalate-alt-ethyloxyphosphate]-co-1,4-bis(hydroxyethyl)terephthalate-co-terephthalate THF: insoluble, but swells
chloroform: soluble
hexane: insoluble, but swells
659606 Poly[(lactide-co-ethylene glycol)-co-ethyloxyphosphate] THF: soluble (readily)
acetonitrile: soluble (readily)
chloroform: soluble (readily)
ethyl acetate: soluble (readily)
hexane: insoluble