Monoclonal Antibodies
Process Development and Application Expertise

Upstream

It all starts here – a robust, cost-effective upstream process is the foundation for successful development of a new biologic. Get a head start on your upstream process with accelerated cell line development and consistent performance during scale-up.


1. Increasing Speed to Market with Confidence by Streamlining the Cell Line Development Process

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The first step in development of a new biologic is creation of a clonal cell line that delivers the molecule of interest with high productivity, the right quality attributes and suitable growth characteristics. Unfortunately, this is time-consuming, labor-intensive and costly.

The CHOZN® platform allows for more rapid clone selection when isolating production cell lines and can save up to 8 weeks in your development time.


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2. Achieving Consistent Process Performance from Small-scale Flasks Through 50 L Bioreactor

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Upstream process development and bioreactor scale-up can be time-consuming, resource-intensive processes. Variability in cell lines plus the need to optimize media formulations add to the number of studies required to obtain a stable, productive and scalable process.

We can accelerate and simplify your upstream process development with a robust, turnkey platform including DNA vectors, modified cell lines, chemically defined cell culture media and single-use bioreactors. Use this complete solution to consistently achieve the desired level of performance across different scales with minimal process optimization.

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