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765503

Gold nanoparticles

20 nm diameter, carboxylic acid functionalized, PEG 3000 coated, OD 50, dispersion in H2O

Synonyme(s) :

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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A propos de cet article

NACRES:
NA.23
UNSPSC Code:
12162002
Service technique
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material

PEG 3000

Quality Segment

100

form

dispersion in H2O, nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

20 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

520 nm

functional group

carboxylic acid

storage temp.

2-8°C

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between the negatively charged carboxylate groups and positively charged amino groups of protein. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.

Application

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
  • Carboxylic acid end-groups bind with various proteins and hence are used in targeted drug delivery and gene therapy.

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Classe de stockage

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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