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765643

Gold nanoparticles

40 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O

Sinónimos:

Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid

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Acerca de este artículo

NACRES:
NA.23
UNSPSC Code:
12162002


material

PEG 5000

Quality Segment

form

dispersion in H2O, nanoparticles

packaging

glass bottle of 1 mL

OD

50

diameter

40 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

functional group

methoxy

storage temp.

2-8°C

General description

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coatings are possible on smaller AuNPs. The methyl group, being hydrophobic, acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.†††

Application

Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and also may used be in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.[1][2]

Features and Benefits

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.


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Clase de almacenamiento

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. How many mg of Gold are in 1 ml of the dispersion?

    1 answer
    1. Each ml of this particular product contains approximately 2.5mg of gold nanoparticles.

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