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Gold nanoparticles
15 nm diameter, OD 50, methyl terminated, PEG 5000 coated, dispersion in H2O
Synonym(e):
Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
1 mL | Warenkorb auf Verfügbarkeit prüfen | € 697,00 |
Über diesen Artikel
NACRES:
NA.23
UNSPSC Code:
12162002
Technischer Dienst
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Unterstützung erhaltenmaterial
PEG 5000
Quality Segment
form
dispersion in H2O, nanoparticles
packaging
poly bottle of 1 mL
OD
50
diameter
15 nm
pH
6.0-8.0 (25 °C)
solubility
water: miscible
density
1.00 g/cm3
λmax
520 nm
functional group
methoxy
storage temp.
2-8°C
General description
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. AuNPs are shown to be highly sensitive colloidal biosensors. The poly (ethylene) glycol (PEG) coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles.PEG layer density depends inversely on the AuNP curvature. AuNPs coated with PEG 5000 exhibited the highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.[1][2]
Application
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
- Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also used in biodistribution studies.
- AuNPs may also be used in photothermal therapy and radiotherapy.
- AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen, when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.[1][2]
Features and Benefits
PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.
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Dieser Artikel | |
|---|---|
| functional group methoxy | functional group amine |
| form dispersion in H2O, nanoparticles | form dispersion in H2O, nanoparticles |
| storage temp. 2-8°C | storage temp. 2-8°C |
| solubility water: miscible | solubility water: miscible |
| density 1.00 g/cm3 | density 1.00 g/cm3 |
| material PEG 5000 | material PEG 5000 |
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Lagerklasse
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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