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1.00202

N,N-Diméthylformamide

for headspace gas chromatography SupraSolv®

Synonyme(s) :

DMF, NSC 5356

pour consulter les tarifs organisationnels et contractuels.

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À vous/RéférenceDisponibilitéPrix
0.5 L

Date d'expédition estimée le05 août 2026DeMerck Life Science BV/SRL

149,00 €
1 L

Date d'expédition estimée le08 juillet 2026DeMerck Life Science BV/SRL

214,00 €
2.5 L

Date d'expédition estimée le29 juin 2026DeMerck Life Science BV/SRL

400,00 €

A propos de cet article

Formule linéaire :
HCON(CH3)2
Numéro CAS:
68-12-2
Poids moléculaire :
73.09
UNSPSC Code:
12191502
NACRES:
NA.03
EC Index Number:
200-679-5
MDL number:
MFCD00003284
Beilstein/REAXYS Number:
605365
Assay:
≥99.8% (GC)
Technique(s):
GC-HS: suitable
Bp:
153 °C (lit.)
Vapor pressure:
2.7 mmHg ( 20 °C)

149,00 €

Date d'expédition estimée le05 août 2026Détails

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Quality Segment

100

agency

according to Ph. Eur., according to USP

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

product line

SupraSolv®

assay

≥99.8% (GC)

form

liquid

autoignition temp.

833 °F

potency

3010 mg/kg LD50, oral (Rat), 1500 mg/kg LD50, skin (Rabbit)

contains

2-Methyl-2-butene as stabilizer

expl. lim.

15.2 %

technique(s)

GC-HS: suitable

impurities

≤1 μg/g Every residual solvent of class 1 acc. to ICH, ≤10 μg/g Every residual solvent of class 2 acc. to ICH, ≤50 μg/g Every residual solvent of class 3 acc. to ICH, ≤0.05% Water

evapn. residue

≤3.0 mg/L

color

APHA: ≤10

refractive index

n20/D 1.430 (lit.)

pH

7 (20 °C, 200 g/L in H2O)

bp

153 °C (lit.)

mp

−61 °C (lit.)

transition temp

flash point 57.5 °C

density

0.944 g/mL (lit.)

SMILES string

[H]C(=O)N(C)C

storage temp.

2-30°C

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

General description

SupraSolv® for headspace gas chromatography (GC-HS) is a dedicated high-purity solvent grade specifically formulated to meet the stringent analytical demands of residual solvent determination in pharmaceutical active pharmaceutical ingredients (APIs), drug products, and other regulated matrices.In headspace GC, the solvent serves as the diluent medium in which the sample is dissolved prior to equilibrium partitioning of volatile analytes into the gaseous headspace phase for subsequent chromatographic injection. Consequently, the chemical purity of the solvent is of critical analytical importance: any residual volatile impurities intrinsic to the solvent matrix may co-elute with target analytes, generating false-positive signals or suppressing accurate quantification. SupraSolv® headspace solvents are therefore specifically developed and tested to contain extremely low concentrations of residual solvents, as mandated by regulatory guidelines.

Application

SupraSolv® headspace GC solvents are indispensable in pharmaceutical residual solvent testing, polymer and excipient quality control, food packaging safety assessment, and industrial material characterization — analytical contexts in which solvent purity is a direct regulatory and safety requirement, and where the integrity of trace-level volatile quantification is non-negotiable.
Solvant pour de nombreux composés organiques hydrophobes

Features and Benefits

  • Regulatory compliance with ICH Q3C, Ph. Eur., and USP residual solvent guidelines, directly supporting pharmaceutical quality control workflows
  • Ultra-low intrinsic volatile impurity content, eliminating solvent-derived interferences in the headspace chromatogram and ensuring an unobstructed baseline
  • Batch-to-batch consistency, ensuring reproducibility across analytical campaigns

Analysis Note

SupraSolv® headspace solvents adhere to the residual solvent classification thresholds defined by the International Council for Harmonisation (ICH Q3C) and referenced in pharmacopoeial standards (Ph. Eur. and USP), with certified limits including:
  • Class 1 solvents (known human carcinogens / environmental hazards): ≤ 1 µg/g
  • Class 2 solvents (non-genotoxic, dose-dependent toxicants): ≤ 10 µg/g
  • Class 3 solvents (low toxic potential): ≤ 50 µg/gThese specifications are verified lot-by-lot via GC/HS analysis, providing robust certification of compliance and analytical traceability.

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

SUPRASOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

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Sigma-Aldrich

319937

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N,N-Diméthylformamide analytical standard

Supelco

72438

N,N-Diméthylformamide

technique(s)

GC-HS: suitable

technique(s)

gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

assay

≥99.8% (GC)

assay

≥99.8% (GC)

assay

≥99.8%

assay

≥99.9% (GC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

form

liquid

form

liquid

form

liquid

form

-

density

0.944 g/mL (lit.)

density

0.944 g/mL (lit.)

density

0.944 g/mL (lit.)

density

0.944 g/mL (lit.)

pH

7 (20 °C, 200 g/L in H2O)

pH

7 (20 °C, 200 g/L in H2O)

pH

7 (20 °C, 200 g/L)

pH

-

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Classe de stockage

3 - Flammable liquids

wgk

WGK 2

flash_point_f

135.5 °F - closed cup

flash_point_c

57.5 °C - closed cup

Listes réglementaires

Les listes réglementaires sont principalement fournies pour les produits chimiques. Seules des informations limitées peuvent être fournies ici pour les produits non chimiques. L'absence d'indication signifie qu'aucun des composants n'est répertorié. Il incombe à l'utilisateur de s'assurer de l'utilisation sûre et légale du produit.

68-12-2

CAS No.

68-12-2

CAS No.

Certificats d'analyse (COA)

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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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