MATHKSA
HKSANon-Endotoxin Pyrogen (NEP) Control
for use with PyroMAT® System
Synonym(s):
NEP, NEP control
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Estimated to ship on14 July 2026fromMerck Chemicals and LS SA | €541.00 |
About This Item
NACRES:
NA.24
UNSPSC Code:
41116130
Suitability:
pyrogenic bacteria
Manufacturer/tradename:
PyroMAT®
Application(s):
pharmaceutical
pyrogen testing
pyrogen testing
Storage temp.:
2-8°C
Quality Segment
product line
PyroMAT®
packaging
pkg of 1 vial
manufacturer/tradename
PyroMAT®
application(s)
pharmaceutical
pyrogen testing
compatibility
for use with PyroMAT® System
shipped in
ambient
storage temp.
2-8°C
suitability
pyrogenic bacteria
General description
The PyroMAT® System uses cryopreserved Mono-Mac-6 (MM6) human monocytic cells as a source of monocytes. The response to a full range of pyrogens, including endotoxins and non-endotoxin pyrogens (NEPs) is determined by the measurement of interleukin-6 (IL-6) produced by the Mono-Mac-6 cells using ELISA. NEP control HKSA is a heat-killed preparation of Staphylococcus aureus, supplied in a lyophilized form. HKSA is a non-endotoxin pyrogen (NEP) that activates the TLR2 receptor of monocytes and can be used as a positive control with the PyroMAT® System (Monocyte Activation Test for pyrogen detection).
Application
NEP control of heat-killed Staphylococcus aureus can be used as a positive control with the PyroMAT® System. It is to be used for Product Specific Validation (PSV) and routine testing to show that the system can detect non-endotoxin pyrogen contaminants in pharmaceutical products.
Biochem/physiol Actions
TLR-2 agonist
Features and Benefits
Endotoxin-free product at concentration of use in MAT
Preparation Note
Store unopened vials at 2-8°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Do not use unopened vials after expiration date
Store resuspended aliquots at -20°C
Legal Information
PYROMAT is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
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