抗一酸化窒素合成酵素, 脳 (1409-1429) ウサギ宿主抗体

In humans, nitric oxide synthase 1 (NOS1) or neuronal nitric acid synthase (nNOS) is localized to the sarcoplasmic reticulum. The gene encoding it is, localized on human chromosome 12q24.22. In rats, the protein is present in perivascular nerves supplying the cerebral vasculature. The gene encoding it is localized on rat chromosome 12q16.

The nitric oxide synthase (NOS) isoform found in neurons is a 150-160 kDa protein. It is also termed brain NOS, NOS1, neuronal NOS (nNOS or bNOS, neuronal constitutive NOS or Ca²⁺-regulated NOS (cNOS, ncNOS). The nNOS or NOS1 gene is mapped to human chromosome 12q24.22. bNOS is present in skeletal muscle, central, peripheral neurons and neuronal cell bodies. Human bNOS and endothelial nitric oxide synthase (eNOS) share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity. Structurally NOS exists as homodimers. The N-terminal region comprises heme and calmodulin binding sites. The reduced nicotinamide adenine dinucleotide phosphate (NADPH) and flavins binding regions are localized in C-terminal region.

ラット脳由来の一酸化窒素合成酵素(NOS)(bNOS、アミノ酸1409~1429番目) に相当する合成ペプチドで、KLHにコンジュゲ-トされています。この免疫原の配列は、ヒト bNOS とはアミノ酸残基１個だけ異なります。

Anti-Nitric Oxide Synthase, Brain (1409-1429) antibody produced in rabbit has been used in:

• immunoblotting[1]
• immunostaining[1]
• immunohistochemistry
• immunofluorescence
• immunocytochemistry

Nitric oxide synthase (NOS), brain (nNOS or bNOS) mediates long-term regulation of synaptic transmission (long-term potentiation, long-term inhibition). It catalyzes the production of nitric oxide (NO) from L-arginine. The NO mediates neurovascular coupling and is associated with neuronal plasticity and pain signal transmission. nNOS regulates blood pressure, relaxation of smooth muscle and vasodilatation via peripheral nitrergic nerves. nNOS is complexed to dystrophin. However, in Duchenne muscular dystrophy (DMD), the skeletal muscle sarcolemma is devoid of nNOS.

The antibody is specific for nitric oxide synthase (NOS) derived from brain. It does not recognize NOS derived from activated macrophages (iNOS) and endothelial cells (eNOS).

15 mMアジ化ナトリウム含有のpH 7.4の0.01 Mリン酸緩衝食塩水溶液

Store at 2-8 °C for up to one month. For extended storage, solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

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