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R4155

Anti-hnRNP-E1/E2 (N-terminal) antibody produced in rabbit

Name: Anti-hnRNP-E1/E2 (N-terminal) antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-HNRPE1/HNRPE2, Anti-Heterogeneous nuclear ribonucleoprotein E1/E2, Anti-PCBP1/PCBP2, Anti-poly(rC) binding protein 1 /protein 2

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NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

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Propiedades

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~37 kDa

species reactivity

human, rat, mouse

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using K562 cell extract, western blot: 0.5-1 μg/mL using K562 cell extract

UniProt accession no.

Q15365

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PCBP1(5093)
mouse ... Pcbp1(23983)
rat ... Pcbp1(500242)

Descripción

General description

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) belongs to hnRNP (heterogeneous ribonucleoprotein) family. It is also known as poly-C binding proteins (PCBP) 1 and 2. It is located on chromosome 2p13. PCBP1 gene has no intron and codes for a 356 amino acid poly (rC) binding protein 1, that is of 35kDa. It has three K-Homology (KH) domains and two nuclear localization signals.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

hnRNP-E1/E2 (heterogeneous nuclear ribonucleoproteins) participates in the development and progression of tumor. It is involved in several transcriptional and posttranscriptional events like mRNA transcription regulation, transportation, splicing, translation, and stabilization. It plays critical roles in cancer apoptosis, metastasis, invasion and malignant transformation. It may also participates in epithelial-mesenchymal transition (EMT).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c