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Monoclonal Anti-Tubulin, Acetylated antibody produced in mouse

Name: Monoclonal Anti-Tubulin, Acetylated antibody produced in mouse
Brand: SIGMA
Price: 504 EUR
Availability: InStock

clone 6-11B-1, ascites fluid

Synonym(s):

Anti-ALS22, Anti-H2-ALPHA, Anti-TUBA1

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromLyon	€504.00
0.2 mL	Available to ship TODAYfromLyon	€648.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164512

Conjugate:

unconjugated

Clone:

6-11B-1, monoclonal

Application:

DB, ELISA (i), EM, ICC, RIA, WB

Citations:

1333

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

6-11B-1, monoclonal

contains

15 mM sodium azide

species reactivity

mouse, protista, invertebrates, hamster, plant, frog, rat, monkey, pig, bovine, chicken, human

technique(s)

dot blot: suitable, electron microscopy: suitable, immunocytochemistry: suitable, indirect ELISA: suitable, radioimmunoassay: suitable, western blot: 1:2,000 using a bovine or rat brain preparation

isotype

IgG2b

UniProt accession no.

P68366

application(s)

research pathology

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TUBA4A(7277)
mouse ... Tuba1a(22142)
rat ... Tuba1a(64158)

Description

General description

α-tubulin, also called as tubulin α 4a (TUBA4A), is mapped to human chromosome 2q35. The gene codes for a member of the α-tubulin family containing 448 amino acids. TUBA4A belongs to the subfamily of tubulin, which is the major building block of microtubules. α-subunit of tubulin has molecular weight of 50,000.

Immunogen

acetylated α-tubulin from the outer arm of sea urchin sperm axonemes.

Application

Monoclonal Anti-Tubulin, Acetylated antibody produced in mouse has been used in following studies:

immunofluorescence.
western blotting.[1]
immunocytochemistry.
immunohistochemistry.[2]

Biochem/physiol Actions

Acetylated tubulin is associated with axoneme assembly in a variety of organisms. Acetylated tubulin might play a crucial role in the differentiation of microtubule structure and function. Post translational modification of α-tubulin i.e. the reversible addition of an acetyl group to Lys40, by specific acetylase, results in acetylated tubulin.

The antibody recognizes an epitope located on the α3 isoform of Chlamydomonas axonemal α-tubulin, within four residues of Lys-40 when this amino acid is acetylated. A sequence very similar to the one detected by the antibody in Chlamydomonas is found in the majority of α-tubulins, but the corresponding region is markedly divergent in some α-tubulin isoforms from chicken, Drosophila and yeast. The antibody has been used to detect acetylated α-tubulins in several organisms. Occasionally, the epitope recognized by the antibody may be absent or masked as it is in the kangaroo rat epithelial-like cell line PtK₂.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	T5168	T9026	T5293
Sigma-Aldrich T6793 Monoclonal Anti-Tubulin, Acetylated antibody produced in mouse	Sigma-Aldrich T5168 Monoclonal Anti-α-Tubulin antibody produced in mouse	Sigma-Aldrich T9026 Monoclonal Anti-α-Tubulin antibody produced in mouse	Sigma-Aldrich T5293 Monoclonal Anti-β-Tubulin antibody produced in mouse
description clone 6-11B-1, ascites fluid	description ascites fluid, clone B-5-1-2	description clone DM1A, ascites fluid	description clone 2-28-33, ascites fluid
clone 6-11B-1, monoclonal	clone B-5-1-2, monoclonal	clone DM1A, monoclonal	clone 2-28-33, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... TUBA4A(7277) mouse ... Tuba1a(22142) rat ... Tuba1a(64158)	Gene Information human ... TUBA4A(7277) mouse ... Tuba1a(22142) rat ... Tuba1a(64158)	Gene Information human ... TUBA4A(7277) mouse ... Tuba1a(22142) rat ... Tuba1a(64158)	Gene Information human ... TUBB1(81027), TUBB2A(7280), TUBB2C(10383) rat ... Tubb2(29212), Tubb2c(296554)
species reactivity mouse, protista, invertebrates, hamster, plant, frog, rat, monkey, pig, bovine, chicken, human	species reactivity mouse, chicken, Chlamydomonas, African green monkey, human, rat, bovine, sea urchin, kangaroo rat	species reactivity yeast, mouse, amphibian, human, rat, chicken, fungi, bovine	species reactivity Ciona intestinalis, rat, chicken, Caenorhabditis elegans, Strongylocentrotus purpuratus, bovine, human
antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid	antibody form ascites fluid
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c