The stability of this material in solution has not been investigated. However, other sources indicate that this compound is soluble in water at >35 mg/mL as well as in DMSO up to 65 mg/mL and Ethanol up to 22 mg/mL. Stock solutions may be stable for 1 month at -20°C and possibly 6 – 12 months at -80°C. Avoid repeated freeze/thaw cycles. This information has not been validated.
B8299
N-Butyldeoxynojirimycin
film (dried in situ), ≥98% (TLC)
Synonym(s):
Miglustat, NB-DNJ
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 mg | Please contact Customer Service for Availability | $500.00 | |
| 5 mg | Please contact Customer Service for Availability | $2,010.00 |
About This Item
Empirical Formula (Hill Notation):
C10H21NO4
CAS Number:
Molecular Weight:
219.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
N-Butyldeoxynojirimycin, film (dried in situ)
assay
≥98% (TLC)
Quality Level
form
film (dried in situ)
solubility
water: 9.80-10.20 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
InChI
1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
InChI key
UQRORFVVSGFNRO-UTINFBMNSA-N
Gene Information
human ... UGCG(7357)
General description
N-Butyldeoxynojirimycin is an alkylated product of imino sugar deoxynojirimycin.
Application
N-Butyldeoxynojirimycin has been used:
- in the inhibition of glycolipid synthesis in neuroblastoma cells
- in the inhibition the ceramide-specific glycosyltransferase in hepatocytes
- in the inhibition of β-glucosidase (GBA2) using fluorescence- activity assay in human embryonic kidney (HEK293) cells.[1]
Biochem/physiol Actions
α-glucosidase Inhibitor
N-Butyldeoxynojirimycin is an inhibitor of glucosyltransferase and α-glucosidases. N-Butyldeoxynojirimycin, also known as misglustat, reduces glycolipid levels by substrate reduction therapy (SRT) and is effectively used for the treatment of glycosphingolipid lysosomal storage disorder, Gaucher disease.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) |
| Gene Information human ... UGCG(7357) | Gene Information - | Gene Information - | Gene Information - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form film (dried in situ) | form powder | form powder | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility water: 9.80-10.20 mg/mL, clear, colorless | solubility DMSO: 9.80-10.20 mg/mL, clear to slightly hazy, colorless to yellow | solubility DMF: 9.80-10.20 mg/mL, clear, colorless to light yellow | solubility water: 50 mg/mL |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Beom Hee Lee et al.
Medicine, 96(45), e8492-e8492 (2017-11-16)
Gaucher disease (GD) is caused by a deficiency in the lysosomal enzyme glucocerebrosidase. Enzyme replacement therapy (ERT) is recommended for clinical improvement. The efficacy and safety of a new imiglucerase, Abcertin, were assessed in 7 Egyptian patients with treatment-naïve type
Imiglucerase in the treatment of Gaucher disease: a history and perspective
Deegan PB and Cox TM
Drug design, development and therapy, 6, 81-81 (2012)
How adhesion/growth-regulatory galectins-1 and-3 attain cell specificity: case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane
Kopitz J, et al.
IUBMB Life, 62(8), 624-628 (2010)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B8299-5MG | 04061833627846 |
| B8299-1MG | 04061826740996 |
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How long is B8299 stable when dissolved in water, and at what temperature can I store it when it is in solution?
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