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E7269

Exendin Fragment 9-39

≥95% (HPLC)

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Tamaño de envaseSKUDisponibilidadPrecio
0.1 mg
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MXP 8,750.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C149H234N40O47S
Número CAS:
133514-43-9
Peso molecular:
3369.76
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00283195

MXP 8,750.00

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Quality Level

200

assay

≥95% (HPLC)

form

powder

mol wt

3369.76 g/mol

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

protein expression: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

UniProt accession no.

P01275, P43220

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)CC(C)C)CO)CCCCN)CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C

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Este artículo
A9525G9020E7521
Exendin Fragment 9-39 ≥95% (HPLC)

Sigma-Aldrich

E7269

Exendin Fragment 9-39

Angiotensin II human ≥93% (HPLC), powder

Sigma-Aldrich

A9525

Angiotensin II human

Gastrin I human ≥95% (HPLC), powder

Sigma-Aldrich

G9020

Gastrin I human

L-(+)-Ergothioneine

Sigma-Aldrich

E7521

L-(+)-Ergothioneine

assay

≥95% (HPLC)

assay

≥93% (HPLC)

assay

≥95% (HPLC)

assay

≥98.0%

technique(s)

protein expression: suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

protein expression: suitable

technique(s)

protein quantification: suitable

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01275, P43220

UniProt accession no.

P01019

UniProt accession no.

P01350

UniProt accession no.

-

Application

Exendin Fragment 9-39 has been used to study its effect on basal microvascular permeability.[1]It has also been used as a glucagon-like peptide-1 receptor (GLP-1R) antagonist:

  • to study to determine whether Ex-4 a GLP-1R agonist acts through GLP-1R, in mouse skeletal muscle cell line[2]
  • to study its effects on the adaptation of islets in glucose-dependent insulinotropic polypeptide knockout mice[3]
  • to study its in vivo effects on GLP-1 signaling on insulin response in mice[4]

Biochem/physiol Actions

Exendin Fragment 9-39 is an antagonist of glucagon-like peptide-1 (GLP-1) receptor, and also acts as an inhibitor of the glucose-dependent insulinotropic polypeptide (GIP)-receptor binding. It also prevents the production of cAMP by GIP.[5]GLP-1, along with GIP, acts as a physiological incretin.[6]

Other Notes

Lyophilized from 0.1% TFA in H2O

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000440173
0000440173
0000333489
0000333489
0000251492

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Hannelouise Kissow et al.
Gut, 62(12), 1724-1733 (2012-10-23)
Glucagon-like peptide-2 (GLP-2) has been suggested for the treatment of mucositis, but the peptide has also been shown to accentuate colonic dysplasia in carcinogen-treated mice. Recently, an effect on intestinal growth was discovered for glucagon-like peptide-1 (GLP-1), OBJECTIVE: To determine
Bilal A Omar et al.
Diabetes, 63(1), 101-110 (2013-09-26)
Mice genetically deficient in the glucagon receptor (Gcgr(-/-)) show improved glucose tolerance, insulin sensitivity, and α-cell hyperplasia. In addition, Gcgr(-/-) mice do not develop diabetes after chemical destruction of β-cells. Since fibroblast growth factor 21 (FGF21) has insulin-independent glucose-lowering properties
C M Edwards et al.
Diabetes, 48(1), 86-93 (1999-01-19)
Glucagon-like peptide 1(7-36) amide (GLP-1) is postulated to be the major physiological incretin in humans, but evidence is indirect. We report the first studies examining the physiological role of GLP-1 in the postprandial state in humans using the GLP-1 antagonist
Yang Liu et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 97, 1061-1065 (2017-11-16)
In the early stage of diabetic retinopathy, the damage of retinal ganglion cells already exists, promoting the development of the disease. The aim of this study was to investigate the protective role and the mechanisms of obestatin against H RGC-5
V A Gault et al.
Diabetologia, 46(2), 222-230 (2003-03-11)
This study examined the biological effects of the GIP receptor antagonist, (Pro3)GIP and the GLP-1 receptor antagonist, exendin(9-39)amide. Cyclic AMP production was assessed in Chinese hamster lung fibroblasts transfected with human GIP or GLP-1 receptors, respectively. In vitro insulin release
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SKUGTIN
E7269-.1MG04061833605028

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