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Anti-OMP antibody produced in rabbit

Name: Anti-OMP antibody produced in rabbit
Brand: SIGMA
Price: 524.45 USD
Availability: InStock

~2 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Olfactory Marker Protein

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Pack Size	SKU	Availability	Price
200 μL		Available to ship TODAYfromMILWAUKEE	$617.00 $524.45

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09265364

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~19 kDa

species reactivity

rat, mouse

concentration

~2 mg/mL

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1 of 1

This Item	SAB1401272	M3319	SAB4200249
Sigma-Aldrich O7889 Anti-OMP antibody produced in rabbit	Sigma-Aldrich SAB1401272 Monoclonal Anti-OMP antibody produced in mouse	Sigma-Aldrich M3319 Anti-Mint2 antibody produced in rabbit	Sigma-Aldrich SAB4200249 Anti-PTPN2 antibody produced in rabbit
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 200	Quality Level 100	Quality Level -	Quality Level 200
UniProt accession no. P08523	UniProt accession no. P47874	UniProt accession no. O35431	UniProt accession no. P17706
technique(s) western blot: 0.5-1.0 μg/mL using rat brain (olfactory bulb) extract (S1 fraction).	technique(s) capture ELISA: suitable, western blot: 1-5 μg/mL	technique(s) immunoprecipitation (IP): 5-10 μg using a rat brain extract (S1 fraction)., microarray: suitable, western blot: 0.25-0.5 μg/mL using rat brain extract (S1 fraction)	technique(s) western blot: 1.5-3.0 μg/mL using Jurkat cell extracts, rat kidney extracts (S1 fraction) or mouse kidney extracts (S1 fraction).

General description

Olfactory marker protein (OMP) is a phylogenetically conserved, 19kDa, cytoplasmic protein of unknown function expressed almost exclusively in mature olfactory sensory neurons, in essentially all vertebrate species. The gene encoding OMP is localized on rat chromosome 1. OMP expression is initially detected in rat and mouse embryo during the last trimester of gestation and reaches adult levels at 2-4 weeks postnatally. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Immunogen

synthetic peptide corresponding to amino acids 119-137 located near the C-terminus of rat OMP conjugated to KLH.

Application

Anti-OMP antibody produced in rabbit has been used in immunohistochemistry.

Anti-OMP antibody produced in rabbit has been used in:

immunoblotting
double immunofluorescence
staining

Biochem/physiol Actions

Olfactory marker protein (OMP) helps to modulate the formation and refinement of the olfactory glomerular map. OMP-deficient mice generated by gene targeting in embryonic stem (ES) cells are compromised in their ability to respond to odor stimuli. In the OMP-null mouse, in addition to reduced odorant response, the levels of neural tyrosine hydroxylase (TH) and neuropeptide cholecystokinin (CCK) are severely reduced. It has been suggested that OMP is a novel modulatory component of the odor detection signal transduction cascade that is developmentally and physiologically regulated.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Olfactory bulb increases marker protein in olfactory receptor cells

Chuah MI, et al.

The Journal of Neuroscience, 3(11), 2197-2205 (1983)

Olfactory marker protein (OMP) regulates formation and refinement of the olfactory glomerular map

Albeanu DF, et al.

Nature Communications, 5073-5073 (2018)

Self-directed orofacial grooming promotes social attraction in mice via chemosensory communication.

Yun-Feng Zhang et al.

iScience, 25(5), 104284-104284 (2022-05-20)

Self-grooming is a stereotyped behavior displayed by nearly all animals. Among other established functions, self-grooming is implicated in social communication. However, whether self-grooming specifically influences behaviors of nearby individuals has not been directly tested, partly because of the technical challenge

Cytotoxic effect of 5-bromo-2-deoxyuridine on olfactory epithelium

Raices M, et al.

MOJ proteomics & bioinformatics, 10-15406 (2015)

Olfactory marker protein (OMP) gene deletion causes altered physiological activity of olfactory sensory neurons

Buiakova OI, et al.

Proceedings of the National Academy of Sciences of the USA, 93(18), 9858-9863 (1996)

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Global Trade Item Number

SKU	GTIN
O7889-200UL	04061837721182

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