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PLA0200

Rabbit anti-KPNA3 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

IPOA4, SRP1, SRP1-gamma, SRP1gamma, SRP4, hSRP1, importin alpha 4, importin alpha Q2, importin alpha-3, importin subunit alpha-3, importin subunit alpha-4, importin-alpha-Q2, karyopherin alpha 3, karyopherin alpha 3 (importin alpha 4), karyopherin subunit alpha-3, qip2

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Size/SKUAvailabilityPrice
100 μL
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€413.00

About This Item

NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, IP, WB
Citations:
-

€413.00

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biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunohistochemistry: 1:100- 1:500, immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000- 1:10,000

accession no.

NP_002258.2

UniProt accession no.

O00505

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... KPNA3(3839)

Immunogen

The epitope recognized by PLA0200 maps to a region between residue 1 and 50 of human karyopherin alpha 3 using the numbering given in entry NP_002258.2 (GeneID 3839).

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

Other Notes

KPNA3 (karyopherin alpha 3), also known as importin alpha 4, is a member of the importin alpha family of proteins which includes KPNA1 (importin alpha 5), KPNA2 (importin alpha 1), KPNA3 (importin alpha 4), KPNA4 (importin alpha 3), KPNA5 (importin alpha 6), and KPNA6 (importin alpha 7). The importin alpha family of proteins plays a role in the import of proteins from the cytoplasm to the nucleus. The import of proteins from the cytoplasm to the nucleus involves docking the protein to receptors associated with the nuclear pore complex (NPC) followed by translocation through the nuclear pore. Importin alpha proteins bind the nuclear localization signal (NLS) of cargo proteins and function as adaptor proteins for the nuclear pore receptor KPNB1 (importin beta 1). KPNB1 is responsible for docking the importin-cargo complex to the cytoplasmic side of the NPC for its translocation through the NPC. KPNA3 (Importin alpha 4) and KPNA4 (importin alpha 3) have been reported to mediate the nuclear import of TNF-alpha induced nuclear import of NF-kappaB p50/p65 heterodimers. KPNA3 has also been reported to be responsible for the ligand-independent nuclear translocation of the vitamin D receptor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Sigma-Aldrich

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Rabbit anti-KPNA3 Antibody, Affinity Purified

Anti-Importin alpha-3/Qip1 Antibody, clone 3D10 clone 3D10, from rat

Sigma-Aldrich

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Anti-KPNA3 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB3500561

Anti-KPNA3 antibody produced in rabbit

Anti-KPNA3 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA046852

Anti-KPNA3 antibody produced in rabbit

antibody form

affinity purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

3D10, monoclonal

clone

polyclonal

clone

polyclonal

biological source

rabbit

biological source

rat

biological source

rabbit

biological source

rabbit

species reactivity

human

species reactivity

rat, monkey, hamster, bovine, human, mouse

species reactivity

mouse, rat, human

species reactivity

human

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

UniProt accession no.

O00505

UniProt accession no.

O35343

UniProt accession no.

O00505

UniProt accession no.

O00505

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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