SML2995
Enviroxime
≥98% (HPLC)
Synonym(s):
(E)-(2-Amino-1-(isopropylsulfonyl)-1H-benzo[d]imidazol-6-yl)(phenyl)methanone oxime, (E)-6-[(Hydroxyimino)phenylmethyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine, (E)-LY 122771-72, (E)-LY-122771-72, (E)-LY122771-72, (E)-Viroxime, 6-[(E)-(Hydroxyimino)phenylmethyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine, EvirX, LY 122772, LY-122772, LY122772
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About This Item
Empirical Formula (Hill Notation):
C17H18N4O3S
CAS Number:
Molecular Weight:
358.41
UNSPSC Code:
41121800
NACRES:
NA.21
MDL number:
Pricing and availability is not currently available.
Quality Level
assay
≥98% (HPLC)
form
powder
color
, White to very dark grey
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC(C=CC(/C(C2=CC=CC=C2)=N/O)=C3)=C3N1S(C(C)C)(=O)=O
Biochem/physiol Actions
Enviroxime (LY 122772) is a selective phosphatidylinositol 4-kinase type IIIβ (PI4KB, PI4KIIIβ) inhibitor (IC50 = 60 nM/PI4KB vs. 1.917 µM/PI4KA) with antiviral potency against enteroviruses, including rhinovirus (RV plaque reduction IC50 ≤40 ng/mL; HeLa), poliovirus (PV), coxsackievirus (CV). PI4KB is a host factor essential for enterovirus replication, mutations in viral 3A protein that recruits PI4KB to the replication sites result in enviroxime resistance. Enviroxime is also reported to impede PI4K-independent hepatitis C (HCV) replication at least partially by an inhibitory effect on PI3Ks.
Phosphatidylinositol 4-kinase type IIIβ (PI4KB, PI4KIIIβ) inhibitor with antiviral potency against enteroviruses and hepatitis C (HCV) replication.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Sequence determinants of 3A-mediated resistance to enviroxime in rhinoviruses and enteroviruses
Journal of Virology, 70, 4854-4857 (1996)
Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs
Journal of Clinical Virology, 128, 104334-104334 (2020)
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses
Diabetic Medicine : a Journal of the British Diabetic Association, 37, 1849-1853 (2020)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2995-25MG | 04065269314905 |
| SML2995-5MG | 04065269319016 |