SML3400
NVS-ZP7-7
≥98% (HPLC)
Synonym(s):
(S)-3,4-Difluoro-N-(1-(2′-oxo-2′,3′-dihydro-1′H-spiro[piperidine-4,4′-quinazoline]-1-yl)-3-phenylpropan-2-yl)benzamide, NVP-LMU348
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About This Item
Empirical Formula (Hill Notation):
C28H28F2N4O2
Molecular Weight:
490.54
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
NVS-ZP7-7 is potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-7 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter that increases ER zinc levels. It appears that inhibition of ZIP7 provided significant protection against ferroptosis.
ZIP7 Inhibitor; potent inhibitor of the Notch signaling pathway that induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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