SML3415
HBX 41,108
≥98% (HPLC)
Synonym(s):
7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, HBX 41108, HBX-41108, HBX41108
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About This Item
Empirical Formula (Hill Notation):
C13H3ClN4O
CAS Number:
Molecular Weight:
266.64
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=C2C=CC(Cl)=C1)C3=C2N=C(C(C#N)=N3)C#N
InChI
1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
InChI key
BIGPXXAUSQLTQR-UHFFFAOYSA-N
Biochem/physiol Actions
Catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease USP7 inhibitor.
HBX 41,108 is a catalytic site-targeting, uncompetitive, potent and reversible ubiquitin-specific protease (USP) inhibitor (USP7/HAUSP IC50 = 420 nM) with little potency toward aspartic, serine or other non-USP cysteine proteases. HBX 41,108 exhibits antiproliferation potency in cancer cultures (HCT116 GI50 = 1 μM post 24 h treatment) by preventing USP7-mediated p53 deubiquitination and thereby promoting p53 target genes expression and inducing p53-dependent apoptosis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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