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SML3450

PA-8

≥95% (HPLC)

Synonym(s):

2-​Amino-​5,​8-​dihydro-​5-​[3-​methoxy-​4-​(2-​propen-​1-​yloxy)​phenyl]​-pyrido[2,​3-​d]​pyrimidine-​4,​7(3H,​6H)​-​dione, PA 8

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About This Item

Empirical Formula (Hill Notation):
C17H18N4O4
CAS Number:
878437-15-1
Molecular Weight:
342.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD07400226
Assay:
≥95% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

PA-8 is a potent and selective PACAP type I (PAC1) receptor agonist that inhibits the phosphorylation of CREB induced by PACAP in PAC1- receptor-expressing CHO cells. PA-8 blocks PACAP-induced aversive responses and mechanical allodynia in mice.
Potent and selective PACAP type I (PAC1) receptor antagonist.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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