SML3490
FMC
≥98% (HPLC)
Synonym(s):
Dimethyl(fluoromethyl)(2-hydroxyethyl)ammonium chloride, Fluorocholine chloride, Fluoromethylcholine chloride, N-(Fluoromethyl)-2-hydroxy-n,n-dimethylethanaminium chloride, NSC720948
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About This Item
Empirical Formula (Hill Notation):
C5H13FNO·Cl
CAS Number:
Molecular Weight:
157.61
UNSPSC Code:
41106300
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
(Crystals to semi-solid)
Storage condition:
under inert gas
Quality Segment
assay
≥98% (HPLC)
form
(Crystals to semi-solid)
storage condition
under inert gas
color
colorless to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
FC[N+](CCO)(C)C.[Cl-]
InChI
1S/C5H13FNO.ClH/c1-7(2,5-6)3-4-8;/h8H,3-5H2,1-2H3;1H/q+1;/p-1
InChI key
QJEHIIJVWXGJAB-UHFFFAOYSA-M
Biochem/physiol Actions
FMC is a monofluorinated choline that acts as a nonlethal, mechanism-based irreversible inhibtor (pseudosubstrate-based suicide inhibitor) against gut anaerobic bacterial glycyl radical enzyme (GRE) cutC choline trimethylamine (TMA) lyase-catalyzed TMA production from choline (IC50 = 0.9 nM/P. mirabilis & 1.4 nM/D. alaskensis rec. CutC/D) without affecting the bacterial growth (P. mirabilis, E. fergusonii, and P. penneri). A single FMC oral dose (100 mg/kg) to mice on choline-supplemented diet significantly reduces plasma trimethylamine N-oxide (TMAO) level (up to 3 days) as well as diet-induced platelet responsiveness and thrombus formation without toxicity or increased bleeding risk.
Orally active gut bacterial choline trimethylamine (TMA) lyase cutC inhibtor with TMA- & TMA N-oxide (TMAO)-lowering efficacy in vitro and in vivo.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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