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SML3667

SR11302

≥98% (HPLC)

Synonym(s):

(E,E,Z,E)-3-Methyl-7-(4-methylpheny­l)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-n­onatetraenoic acid, SR 11302, SR-11302

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About This Item

Empirical Formula (Hill Notation):
C26H32O2
CAS Number:
160162-42-5
Molecular Weight:
376.53
MDL number:
MFCD09038562
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

General description

Conformationally restricted anti-AP-1 retinoid that selectively induces receptors-mediated AP-1 inhibition, but not transcription activation.

SR11302 is a conformationally restricted anti-AP-1 retinoid that selectively induces receptors-mediated AP-1 inhibition (RARα > RARγ > RXRα = RARβ), but not transcription activation (25-fold vs no RARα enhancement by 1 μM t-RA or 10 μM SR11302, respectively). Unlike t-RA, SR11302 inhibits the proliferation of cancer cultures (1 μM; Calu-6, HeLA, T47D) without inducing the differentiation of F9 cells (0.1-1 μM).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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