SML3688
Hypoxia probe 4
≥95% (HPLC)
Synonym(s):
5-Methoxy-1,2-dimethyl-3-(((3-oxo-9-(O-tolyl)-3H-xanthen-6-yl)oxy)methyl)-1H-indole-4,7-dione
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About This Item
Empirical Formula (Hill Notation):
C32H25NO6
Molecular Weight:
519.54
UNSPSC Code:
41116158
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
protect from light
Quality Segment
assay
≥95% (HPLC)
form
powder
storage condition
protect from light
color
, Faint yellow to yellow-brown
solubility
DMSO: 2 mg/mL, clear
shipped in
wet ice
storage temp.
-10 to -25°C
SMILES string
CN1C(C(C=C2OC)=O)=C(C2=O)C(COC3=CC=C(C(C4=CC=CC=C4C)=C5C=C6)C(OC5=CC6=O)=C3)=C1C
InChI
1S/C32H25NO6/c1-17-7-5-6-8-21(17)29-22-11-9-19(34)13-26(22)39-27-14-20(10-12-23(27)29)38-16-24-18(2)33(3)31-25(35)15-28(37-4)32(36)30(24)31/h5-15H,16H2,1-4H3
InChI key
MQKQLIOGOATWPT-UHFFFAOYSA-N
Biochem/physiol Actions
Hypoxia probe 4 is a Tokyo green-based non-fluorescent hypoxia probe that undergoes cytochrome P450 reductase (PH51)-catalyzed reduction to yield the fluorescent reporter Tokyo green (ex 480 nm, em 515 nm) in conditions of 0.5% O2 and lower, allowing imaging hypoxia levels similar to those detected by EF5 without the use of antibodies. When employed together with resorufin-based hypoxia probe 2 (ex 545 nm, em 582 nm), the probe pair allows the simultaneous (two-color) imaging of different hypoxia levels in living cells.
Tokyo green-based hypoxia probe that allows fluorescent imaging of hypoxia levels in live cells similar to those detected by EF5 without the use of antibodies.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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