SML3720
PHA-793887
≥98% (HPLC)
Synonym(s):
N-{6,6-Dimethyl-5-[(1-methylpiperidin-4-yl)carbonyl]-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl}-3-methylbutanamide, PHA 793887, PHA793887
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About This Item
Empirical Formula (Hill Notation):
C19H31N5O2
CAS Number:
Molecular Weight:
361.48
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
N1(CCC(CC1)C(=O)N2C(c3n[nH]c(c3C2)NC(=O)CC(C)C)(C)C)C
InChI
1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25)
InChI key
HUXYBQXJVXOMKX-UHFFFAOYSA-N
Biochem/physiol Actions
Highly potent and selective pan-CDK inhibitor with anti-cancer efficacy in cultures and in vivo.
PHA-793887 is a highly potent and selective pan-CDK inhibitor (CDK1/2//4/5/7/9 IC50 5-140 nM; IC50 >10 μM against 34 other kinases) with anti-proliferative activity against several solid tumor cell lines (IC50 <1 μM) by blocking Rb phosphorylation and the expression of S-phase cyclins, such as cyclin A. PHA-793887 exhibits in vivo anti-leukemia efficacy in murine xenograft models (20 mg/kg via daily i.v.; HL60, K562, ALL-2 or AML-PS).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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