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SML3723

JNJ-26854165

≥98% (HPLC)

Synonym(s):

1-N-[2-(1H-Indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine, JNJ 1, JNJ 26854165, N1-[2-(1H-Indol-3-yl)ethyl]-N4-4-pyridinyl-1,4-benzenediamine, Serdemetan

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About This Item

Empirical Formula (Hill Notation):
C21H20N4
CAS Number:
881202-45-5
Molecular Weight:
328.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD16620518
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[nH]1c2c(c(c1)CCNc3ccc(cc3)Nc4ccncc4)cccc2

InChI key

CEGSUKYESLWKJP-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of the E3 ligase human double minute-2 (HDM2); cholesterol transport inhibitor
JNJ-26854165 (serdemetan) is an inhibitor of the E3 ligase human double minute-2 (HDM2) that inhibits cell proliferation and induces apoptosis in models of acute myeloid and lymphoid leukemias, and solid tumors. Also JNJ-26854165 inhibits cholesterol transport. JNJ-26854165 appears to stimulate cholesterol regulatory genes, but simultaneously inhibits cholesterol transport.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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