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SML3825

MM0299

≥98% (HPLC)

Synonym(s):

4,4a,5,5a,6,6a-Hexahydro-2-[4-[2-(4-methoxyphenyl)-2-oxoethoxy]phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione

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About This Item

Empirical Formula (Hill Notation):
C26H23NO5
CAS Number:
474255-10-2
Molecular Weight:
429.46
UNSPSC Code:
51111800
NACRES:
NA.21
MDL number:
MFCD03145757
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Cell penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity
MM0299 is a cell penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol. MM0299 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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