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SML3939

Org 34167

≥98% (HPLC)

Synonym(s):

(αS)-2-(1,2-Benzisoxazol-3-yl)-α-2-propen-1-ylbenzenemethanamine, (1S)-1-(2-(1,2-Benzoxazol-3-yl)phenyl)but-3-en-1-amine, (S)- 2-(1,2-Benzisoxazol-3-yl)-α-2-propenyl-benzenemethanamine, ORG-34167

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About This Item

Empirical Formula (Hill Notation):
C17H16N2OHCl
CAS Number:
198966-49-3
Molecular Weight:
300.78
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

C=CC[C@H](N)C(C=CC=C1)=C1C2=NOC3=CC=CC=C32.Cl

Biochem/physiol Actions

Brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity.
Org 34167 is a brain penetrant, potent and selective modulator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that exhibit antidepressant activity in human and rat models. Apparently, Org 34167 inhibits HCN1 channel activity by modulating hyperpolarizing shift in activation voltage dependence and a slowing of activation kinetics.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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