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SML3966

Arborinine

≥98% (HPLC)

Synonym(s):

1-Hydroxy-2,3-dimethoxy-10-methyl-9(10H)-acridinone, 1-Hydroxy-2,3-dimethoxy-10-methylacridan-9-one, 1-Hydroxy-2,3-dimethoxy-10-methylacridone, Arborinin

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About This Item

Empirical Formula (Hill Notation):
C16H15NO4
CAS Number:
5489-57-6
Molecular Weight:
285.29
MDL number:
MFCD00060475
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C1C2=C(C=C(C(OC)=C2O)OC)N(C)C3=C1C=CC=C3

Biochem/physiol Actions

Alkaloid isolated from leaves of Glycosmis bilocularis that exhibits strong anti-cancer, anti-bacterial, and anti-viral activities.
Arborinine is a quinoline alkaloid isolated from leaves of Glycosmis bilocularis that exhibits strong anti-cancer, anti-bacterial, and anti-viral activities. Arborinine is a broad-spectrum antiproliferative agent, which potently inhibits proliferation of numerous cancer cell lines including NCI-N87 (IC50 = 5.67 μM), BGC-823 (IC50 = 7.26 μM), MGC803 (IC50 = 4.75 μM) and more. It potently inhibits SKOV3 ovarian carcinoma cell proliferation and tumor growth. It also reduces migration and invasion of SKOV3 cancer cells. Arborinine reduces expression of histone demethylase LSD1, which leads to accumulation of H3K4m1.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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