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SML4076

VU0542270

≥98% (HPLC)

Synonym(s):

N-[[4-Methyl-2-(2-thienyl)-5-thiazolyl]methyl]-N′-2-thienylurea

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About This Item

Empirical Formula (Hill Notation):
C14H13N3OS3
CAS Number:
1396814-79-1
Molecular Weight:
335.47
MDL number:
MFCD22622541
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(CNC(NC2=CC=CS2)=O)SC(C3=CC=CS3)=N1

Biochem/physiol Actions

Potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels.


VU0542270 is a potent and highly selective inhibitor of vascular Kir6.1/SUR2B (vascular KATP) channels (IC50 ~ 100 nM) that show no apparent activity toward Kir6.2/SUR1 and other members of the Kir channel family. It appears that VU0542270 binds to SUR2. It has a rather short in vivo half-life (t1/2 = 0.64 hour).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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