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About This Item
Empirical Formula (Hill Notation):
C20H14Cl3F6N3O3S
CAS Number:
Molecular Weight:
596.76
MDL number:
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
FC(F)(F)[C@@]2(ONC(=C2)c3[s]c(c(c3)C)C(=O)NCC(=O)NCC(F)(F)F)c1cc(c(c(c1)Cl)Cl)Cl
InChI
1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-5,32H,6-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
InChI key
DPFOXZCPAGCTER-SFHVURJKSA-N
Biochem/physiol Actions
Orally available and potent inhibitor of γ-aminobutyric acid (GABA)-gated chloride channels; parasiticide.
Lotilaner is an oral isooxazoline ectoparasitic veterinary medication used to control fleas and ticks in dogs and cats. Lotilaner, similarly to other isoxazolines, targets gamma-aminobutyric acid (GABA) receptors. It binds to the GABA-gated chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals and leads to paralysis and death.
Lotilaner is an oral isooxazoline ectoparasitic veterinary medication used to control fleas and ticks in dogs and cats. Lotilaner, similarly to other isoxazolines, targets gamma-aminobutyric acid (GABA) receptors. It binds to the GABA-gated chloride channels in nerve and muscle cells, which blocks the transmission of neuronal signals and leads to paralysis and death.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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