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SML4158

TED-347

≥98% (HPLC), powder

Synonym(s):

2-Chloro-1-[2-[[3-(trifluoromethyl)phenyl]amino]phenyl]ethanone

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About This Item

Empirical Formula (Hill Notation):
C15H11ClF3NO
CAS Number:
2378626-29-8
Molecular Weight:
313.70
MDL number:
MFCD32689460
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(C1=CC=CC=C1NC2=CC(C(F)(F)F)=CC=C2)CCl

Application

TED-37 is used to probe the how dyregulation ofYAP-TEAD signalling relates to glioblastoma proliferations.

Biochem/physiol Actions

TED-347is a potent and selective allosteric inhibitor of the transcriptional enhanced associate domain (TEAD)-yes-associated protein 1 (Yap1) protein-protein interaction (EC50 =5.9 µM) that inhibits TEAD transcriptional activity. It potentlyinhibits growth of spheroids of patient-derived GBM43 glioblastoma cell lines.TED-347 binds to the TEAD4 palmitate pocket where it forms covalent bond withCys-367.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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