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SML4164

ATN-161 trifluoroacetate salt

≥95% (HPLC), (Powder or Lyophilized powder or film), integrin α5β1receptor antagonist

Synonym(s):

1-Acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-L-aspartamide trifluoroacetate salt, Ac-PHSCN-NH2 trifluoroacetate salt, Ac-Pro-His-Ser-Cys-Asn-NH2, PHSCN trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C23H35N9O8S · xC2HF3O2
CAS Number:
262438-43-7
Molecular Weight:
597.64 (free base basis)
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Storage condition:
desiccated
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Quality Segment

100

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

SMILES string

O=C([C@H]1N(C(C)=O)CCC1)N[C@@H](CC2=CN=CN2)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CC(N)=O)C(N)=O)=O)=O)=O

Application

ATN-161 trifluoroacetate salt may be used in studies focusing on angiogenesis and cancer research, particularly in the development of models assessing tumor growth and metastasis. It may also be used as a fluorescent probe in research to study cellular processes and interactions due to its ability to bind to integrins.

Biochem/physiol Actions

ATN-161, an antagonist of the integrin α5β1 receptor, is a non-RGD-based integrin binding peptide derived from the synergy region of fibronectin that inhibits the receptors for integrins alpha-v beta-3 and integrin alpha-5 beta-1. Integrin alpha-5 beta-1 is expressed on endothelial cells and plays a key role in endothelial cell adhesion and migration and may also play a key role in cancer cell invasion and metastasis. ATN-161 exhibits antiangiogenic and antitumor activity. This noncompetitive inhibitor of the fibronectin PHSRN sequence has the potential to disrupt the function of various integrins involved in tumor angiogenesis and metastasis. It can inhibit the interaction between the SARS-CoV-2 spike protein and its host binding partners.

Disclaimer

Hygroscopic

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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