Key Documents

View All Documentation

SML4184

Gadobutrol

Name: Gadobutrol
Brand: SIGMA

≥95% (Gadolinium, elemental analysis), powder, Magnetic resonance contrast agent

Synonym(s):

(SA-8-1425362′5′)-[rel-10-[(2R,3S)-2-(Hydroxy-κO)-3-hydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]gadolinium, Gadograf,Protovist, Protovist, K 135079, ZK 135079

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₈H₃₁GdN₄O₉

CAS Number:

770691-21-9

Molecular Weight:

604.71

NACRES:

NA.21

Assay:

≥95% (Gadolinium, elemental analysis)

Form:

powder

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Segment

100

assay

≥95% (Gadolinium, elemental analysis)

form

powder

color

white to beige

solubility

H₂O: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

OC[C@H](N1CCN(CCN(CC([O-])=O)CCN(CC([O-])=O)CC1)CC([O-])=O)[C@@H](O)CO.[Gd+3]

Description

General description

Gadobutrol is a highly water-soluble, macrocyclic, and electrically neutral gadolinium-based contrast agent (GBCA) used in contrast-enhanced MRI. Its active component is a non-ionic, paramagnetic complex of gadolinium (Gd3+) chelated with butrol, forming the distinct gadobutrol structure. Gadobutrol exhibits the greatest shortening of proton T1 relaxation times amongst all macrocyclic GBCAs, a key determinant of signal and contrast enhancement in MRI.

Application

Gadobutrol may be used to enhance diagnostic contrast in magnetic resonance imaging (MRI) of pathological lesions in the liver, central nervous system (CNS), kidney, and brain.

Biochem/physiol Actions

Water-soluble macrocyclic gadolinium-based MRI contrast agent excreted renally, enhances CNS pathology detection by improving blood-brain barrier visualization.
Upon intravenous administration, it enhances MRI sensitivity for detecting CNS pathologies associated with blood-brain barrier defects, areas of altered perfusion, or expanded extracellular space. This agent is particularly effective in visualizing tumors, inflammatory processes, and demyelinating diseases of the CNS. Gadobutrol is eliminated unchanged via the kidneys, with negligible extra-renal excretion.

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library