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SML4190

Ropidoxuridine

≥98% (HPLC), powder, radiosensitizer

Synonym(s):

5-Iodo-2-pyrimidinone-2′-deoxyribose, 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-iodo-2(1H)-pyrimidinone, 1-(2-Deoxy-β-D-ribofuranosyl)-5-iodo-2-pyrimidinone, IPdR

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About This Item

Empirical Formula (Hill Notation):
C9H11IN2O4
CAS Number:
93265-81-7
Molecular Weight:
338.10
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1N(C=C(C=N1)I)[C@@H]2O[C@@H]([C@H](C2)O)CO

General description

Ropidoxuridine, a thymidine analog, is an orally available pro-drug of 5-iodo-2′-deoxyuridine (IUdR).

Application

Ropidoxuridine is suitable for use in radiosensitization studies in vivo using cancer models and cell lines.

Biochem/physiol Actions

Ropidoxuridine, a radiation sensitizer, after oral administration it is metabolized by an aldehyde oxidase in the liver to the active drug. Ropidoxuridine sensitizes cancer cells to radiation.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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