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SML4195

DCZ0415

≥98% (HPLC)

Synonym(s):

2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione, 4,4a,5,5a,6,6a-Hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-4,6-ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, DCZ 0415, DCZ-0415

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About This Item

Empirical Formula (Hill Notation):
C23H20N2O2
CAS Number:
2242470-43-3
Molecular Weight:
356.42
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

DCZ0415 may be used to determine its effects on cell viability, cell cycle distribution, invasive capabilities, and migratory behavior of colorectal cancer (CRC) cells.

Biochem/physiol Actions

DCZ0415 is a TRIP13 inhibitor that exhibits antimyeloma activity in cultures (IC50 in µM = 1.15/U266, 3.25/ARK, 4.13/OCI-MY5, 5.12/ARP-1, 7.4/RPMI-8226, H292/8.02) and in xenograft models in vivo (25 or 50 mg/kg via daily i.p. to mice with MOPC-315 or H929 tumors, respectively) by impairing nonhomologous end-joining (NHEJ) repair and NF-kB activity. Synergistic antimyeloma activity is observed when DCZ0415 is used in combination with the DNA-akylating agent melphalan or the HDAC inhibitor panobinostat.
DCZ0415 also reduces cyclin D1, β-catenin, and T-cell factor 1 levels, resulting in the inactivation of the Wnt/β-catenin pathway.

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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