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SML4207

I4.05

≥98% (HPLC)

Synonym(s):

2-Chloro-5-[5-[[1-(4-fluorophenyl)-3,5-dioxo-4-pyrazolidinylidene]methyl]-2-furanyl]benzoic acid, inhibitor of α-synuclein aggregation I4.05

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About This Item

Empirical Formula (Hill Notation):
C21H12ClFN2O5
CAS Number:
312289-90-0
Molecular Weight:
426.78
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

faint orange to brown

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

I4.05 is an inhibitor of α-synuclein aggregation that bind the catalytic sites on the surface of the aggregates (KD = 68 nM at pH 4.8 and 13 nM at pH 8.0 (binding to the pocket on the αS fibril)). It works against varies patient-derived fibrils, which is in variance to Anle-138b that accelerated aggregation. I4.05 was discovered by machine learning strategy.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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