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SML4240

AFN-1252

≥98% (HPLC), powder, FabI inhibitor

Synonym(s):

(E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide, (2E)-N-Methyl-N-[(3-methyl-2-benzofuranyl)methyl]-3-(5,6,7,8-tetrahydro-7-oxo-1,8-naphthyridin-3-yl)-2-propenamide, Debio 1452, AFN 1252, afabicin pro-drug

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About This Item

Empirical Formula (Hill Notation):
C22H21N3O3
CAS Number:
620175-39-5
Molecular Weight:
375.42
MDL number:
MFCD18633190
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

Application

AFN-1252 may be used to evaluate its inhibitory effect on the growth of Burkholderia pseudomallei bacteria; and has been used in minimal inhibitory concentration (MIC) and rate of kill studies to study its in vitro activity against Staphylococcus aureus.

Biochem/physiol Actions

Debio 1452 (AFN-1252) is an inhibitor of staphylococcal enoyl-acyl carrier protein reductase (FabI), an enzyme critical to fatty acid biosynthesis in Staphylococcus spp.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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