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SML4253

PRGL493

≥98% (HPLC), powder, ACSL4 inhibitor

Synonym(s):

N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide, N-[1,4-Dihydro-4-[3-(5-methyl-2-furanyl)-1-phenyl-1H-pyrazol-4-yl]-1,3,5-triazino[1,2-a]benzimidazol-2-yl]acetamide

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About This Item

Empirical Formula (Hill Notation):
C25H21N7O2
CAS Number:
2479378-45-3
Molecular Weight:
451.48
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

-10 to -25°C

SMILES string

CC(NC1=NC(N2C(C3=CN(C4=CC=CC=C4)N=C3C5=CC=C(C)O5)N1)=NC6=C2C=CC=C6)=O

Application

PRGL493 may be used to study:
  • the role of ACSL4 in endometrial receptivity disorders, using mouse endometriosis model
  • its therapeutic effects in severe acute pancreatitis model in mice

Biochem/physiol Actions

PRGL493, a highly effective and selective Acyl-CoA synthetase 4 (ACSL4) inhibitor, exhibits potent anti-tumor activities by inhibiting cell proliferation and tumor growth in breast and prostate cancer models, both in vitro (IC50 ~ 25 µM) and in vivo (250 μg/kg, i.p., in mice). PRGL493 functions mainly by reducing ABCG2 (ATP-binding cassette subfamily G member 2) in TNBC and promoting ER expression. PRGL-493 effectively disrupts steroidogenesis, demonstrated by the significant reduction of steroid levels in cell lines and mouse models. Additionally, PRGL493 enhances the sensitivity of cancer cells to conventional chemotherapeutic and hormonal treatments.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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