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UC430

1′-Hydroxymidazolam

Name: 1&#8242;-Hydroxymidazolam
Brand: SIGMA

≥97% (HPLC), powder

Synonym(s):

8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₃ClFN₃O

CAS Number:

59468-90-5

Molecular Weight:

341.77

UNSPSC Code:

12161501

PubChem Substance ID:

24724655

NACRES:

NA.77

MDL number:

MFCD00871458

Form:

powder

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Properties

Product Name

1′-Hydroxymidazolam,

form

powder

Quality Segment

200

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to off-white

storage temp.

2-8°C

SMILES string

OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2

InChI key

QHSMEGADRFZVNE-UHFFFAOYSA-N

Description

General description

1′-Hydroxymidazolam is the metabolite of midazolam.

Application

CYP3A4 metabolite of midazolam.

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.

Biochem/physiol Actions

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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