Formulation of Biomolecules

Process Chemicals and Excipients for the Formulation of Biomolecules

We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules.  Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation.

Exemplary Unit Operations of a Biomolecule Downstream Process

Virus Inactivation Chromatography Ultrafiltration/Diafiltration Final Formulation
Virus Inactivation   Chromatography   Ultrafiltration/
Diafiltration
  Final Formulation

Specifically developed for high-risk applications, our buffers, salts and stabilizer are low in bioburden and endotoxins. They are supported by our Emprove® Program and come with extensive documentation, helping you minimize regulatory and quality-associated risks in your biopharmaceutical manufacturing.

Benefit from:

  • Reliable product quality
  • Low microbial and endotoxin load
  • Emprove® Program supporting risk assessment
  • Elemental Impurity Information according to ICH Q3D
  • Paperfree packaging

Product List

Product Number Product Name
100590 Glycine cryst. EMPROVE® EXPERT Ph Eur,BP,JP,USP
101544 L-Arginine monohydrochloride EMPROVE® EXPERT Ph Eur,BP,JP,USP
101587 L-Arginine EMPROVE® EXPERT Ph Eur,JP,USP
102776 Trehalose Dihydrate EMPROVE® EXPERT Ph Eur,NF,JP
103669 Glycine Granules EMPROVE® EXPERT Ph.Eur., BP, JP, USP
103789 Sucrose EMPROVE® EXPERT, low in nanoparticles
104352 L-Histidine EMPROVE® EXPERT Ph Eur,USP,JP
104354 L-Histidine monohydrochloride monohydrate  EMPROVE® EXPERT Ph Eur,BP,JP
111597 Parteck® SI 400 LEX (Sorbitol) suitable for use as excipient EMPROVE® exp Ph Eur,BP,NF,JP
137004 Titriplex® III (EDTA di-sodium salt dihydrate) EMPROVE® EXPERT Ph Eur,BP,ChP,JP,USP,ACS
137028 Glycerol anhydrous (vegetable) suitable for biopharmaceutical production EMPROVE® bio Ph Eur,BP,JP,USP,ACS
137096 D(-) – Mannitol EMPROVE® EXPERT Ph Eur, BP,USP,JP

Citrates

Product Number Product Name
137042 tri-Sodium citrate dihydrate cryst. EMPROVE® EXPERT Ph Eur,BP,JP,USP,ACS
137003 Citric acid monohydrate cryst. EMPROVE® EXPERT Ph Eur,BP,JP,USP,ACS
137002 Citric acid anhydrous powder EMPROVE® EXPERT Ph Eur,BP,JP,USP,ACS

Acetates

Product Number Product Name
137012 Sodium acetate trihydrate EMPROVE® EXPERT Ph Eur,BP,JP,USP
137046 Sodium acetate anhydrous EMPROVE® EXPERT USP

Phosphates

Product Number Product Name
137018 Sodium dihydrogen phosphate dihydrate  EMPROVE® EXPERT Ph Eur,BP,USP,JPE  
137093 Sodium dihydrogen phosphate monohydrate EMPROVE® EXPERT BP,USP
137036 di-Sodium hydrogen phosphate dihydrate  EMPROVE® EXPERT Ph Eur,BP,USP
137092 di-Sodium hydrogen phosphate heptahydrate  EMPROVE® EXPERT DAC,USP

Tris

Product Number Product Name
108307 Tris(Hydroxymethyl)aminomethane (Trometamol) high purity EMPROVE® EXPERT Ph Eur,BP,JPC,USP,ACS 
108219 Tris(hydroxymethyl)aminomethane hydrochloride EMPROVE® EXPERT

Histidine

Product Number Product Name
104352 L-Histidine EMPROVE® EXPERT Ph Eur,USP,JP
104354 L-Histidine monohydrochloride monohydrate EMPROVE® EXPERT Ph Eur,BP,JP

Acids/Bases

Product Number Product Name
137007 HCl fuming 37% EMPROVE® EXPERT Ph Eur,BP,JP,NF,ACS
137000 Acetic acid (glacial) 100% EMPROVE® EXPERT Ph Eur,BP,JP,USP
137020 Sodium hydroxide, pellets EMPROVE® EXPERT Ph Eur, BP, JP, NF, ACS
Product Number Product Name
137017 Sodium chloride EMPROVE® EXPERT Ph Eur,BP,JP,USP 
137009 Potassium chloride EMPROVE® EXPERT Ph Eur,BP,USP,JP
137008 Magnesium chloride hexahydrate EMPROVE® EXPERT Ph Eur, BP, USP, JPC, ACS
137101 Calcium chloride dehydrate EMPROVE® EXPERT Ph Eur, BP, JP, USP
Product Number Product Name
108643 Triton® X-100 EMPROVE® EXPERT Ph Eur
817061 Tween® 80 (Polysorbate), EMPROVE® ESSENTIAL Ph Eur,JP,NF
100002 Tri-n-butyl phosphate EMPROVE® EXPERT Ph Eur
Product Number Product Name
101816 Ammonium sulfate suitable for the biopharmaceutical production EMPROVE® EXPERT ACS,NF
137144 Sodium sulfate anhydrous EMPROVE® EXPERT Ph Eur,USP,BP
137030 Urea cryst. EMPROVE® EXPERT Ph Eur,BP,JP,USP,ACS
137037 Guanidinium chloride EMPROVE® EXPERT
817081 Sodium caprylate suitable for use as excipient EMPROVE® exp Ph Eur,ChP,NF
100193 Caprylic acid (Octanoic acid) EMPROVE® EXPERT Ph Eur,NF
Product Number Product Name
137112 Poloxamer 188 EMPROVE® EXPERT
817072 Tween® 20 (Polysorbate) EMPROVE® ESSENTIAL Ph Eur,JPE,NF
817061 Tween® 80 (Polysorbate), EMPROVE® ESSENTIAL Ph Eur,JP,NF