PLA & PLGA Biodegradable Polymers

sustained drug release

Fine tune your release profile with our PLA & PLGA polymers

Optimize the release kinetics of your final drug products and choose your poly (D,L-lactic acid)(PLA) and/or poly (D,L-lactic-co-glycolic acid) (PLGA) biodegradable polymers from our wide portfolio. You can also use our customization capabilities to manufacture the polymer with the characteristics that you need.

PLA and PLGA-based formulations have widely demonstrated their suitability for the sustained release of therapeutics. The United States Food and Drug Administration and the European Medicines Agency have approved several drug products that are on the market and many more are in clinical development. The reduction of side effects and the improvement of patient comfort and compliance are amongst the reasons for these formulations’ success.

Our polymers are manufactured in Europe and are subject to robust QC specifications which were developed with the end dosage form in mind. Our GMP polymers include specifications such as bioburden and consider elemental impurity requirements based on ICHQ3D. Small, representative non-GMP test packets are available for the full portfolio. We offer both small and large-scale manufacturing following ICHQ7 Chapter 19 standards (for use in clinical trials) and boast an excellent track record of customer and FDA audits. We are your perfect global partner for top-quality biodegradable polymers. Contact us for a consultation.

Benefits of our PLA & PLGA polymer portfolio:

  • Allows optimization of your early formulation without the need of custom manufacturing
  • Both small and large scale GMP manufacturing available based on your needs
  • Technical support, both formulation and analytical, available through our internal experts

Our PLA & PLGA portfolio allows you to find the best polymer for your drug delivery system:

Products are available in non-GMP sample form with pack size of 10g; the following five can be ordered through our online shop, please contact us for other products listed and a quote on GMP manufacturing.

     
Product Order No. Poly
(D, L-lactic acid)
(PLA)
Ratio L/DL End Group I.V. range
(dL/g, CHCl3, 25°C)
MW
(indicative range, kDa)
EXPANSORB® DL 100-1A 5.43108 PDLLA 0/100 COOH 0.05-0.20 6-20
EXPANSORB® DL 100-2A 5.43109 PDLLA 0/100 COOH 0.15-0.30 10-25
EXPANSORB® DL 100-5A 5.43110 PDLLA 0/100 COOH 0.40-0.60 45-80
EXPANSORB® DL 100-7A 5.43111 PDLLA 0/100 COOH 0.60-0.80 70-120
EXPANSORB® DLL 10-15A 5.43112 P(L/DL)LA 90/10 COOH 1.30-1.70 200-250
EXPANSORB® DL 100-2E 5.43113 PDLLA 0/100 ESTER 0.15-0.30 10-25
Product Order No. Poly
(D, L-lactic-co-
glycolic acid)
(PLGA)
Ratio L/DL End Group I.V. range
(dL/g, CHCl3, 25°C)
MW
(indicative range, kDa)
EXPANSORB® DLG 45-2A 5.43114 PLGA 45/55 COOH 0.15-0.30* 15-30
EXPANSORB® DLG 50-2A 5.43115 PLGA 50/50 COOH 0.15-0.25 5-20
EXPANSORB® DLG 50-3A 5.43116 PLGA 50/50 COOH 0.25-0.40 15-40
EXPANSORB® DLG 50-5A 5.43117 PLGA 50/50 COOH 0.40-0.55 42-65
EXPANSORB® DLG 50-6A 5.43118 PLGA 50/50 COOH 0.55-0.65 60-85
EXPANSORB® DLG 50-8A 5.43119 PLGA 50/50 COOH 0.65-0.90 80-130
EXPANSORB® DLG 55-5A 5.43120 PLGA 55/45 COOH 0.40-0.50 42-65
EXPANSORB® DLG 65-3A 5.43121 PLGA 65/35 COOH 0.25-0.35 15-40
EXPANSORB® DLG 65-6A 5.43122 PLGA 65/35 COOH 0.50-0.65 45-85
EXPANSORB® DLG 75-2A 5.43124 PLGA 75/25 COOH 0.08-0.21 5-20
EXPANSORB® DLG 75-5A 5.43125 PLGA 75/25 COOH 0.38-0.64 37-84
EXPANSORB® DLG 75-7A 5.43126 PLGA 75/25 COOH 0.60-0.70 65-85
EXPANSORB® DLG 75-8A 5.43127 PLGA 75/25 COOH 0.70-0.90 76-130
EXPANSORB® DLG 75-10A 5.43123 PLGA 75/25 COOH 0.80-1.10 110-166
EXPANSORB® DLG 85-2A 5.43129 PLGA 85/15 COOH 0.15-0.25 10-15
EXPANSORB® DLG 85-7A 5.43128 PLGA 85/15 COOH 0.55-0.75 65-95
EXPANSORB® DLG 90-5A 5.43130 PLGA 90/10 COOH 0.35-0.55 30-70
EXPANSORB® DLG 90-7A 5.43131 PLGA 90/10 COOH 0.60-0.75 50-95
EXPANSORB® DLG 95-2A 5.43132 PLGA 95/5 COOH 0.15-0.25 5-20
EXPANSORB® DLG 95-4A 5.43133 PLGA 95/5 COOH 0.25-0.50 35-60
EXPANSORB® DLG 50-2E 5.43134 PLGA 50/50 ESTER 0.15-0.25 5-20
EXPANSORB® DLG 50-6E 5.43135 PLGA 50/50 ESTER 0.55-0.65 60-85
EXPANSORB® DLG 50-7E 5.43136 PLGA 50/50 ESTER 0.60-0.70 70-100
EXPANSORB® DLG 65-6E 5.43137 PLGA 65/35 ESTER 0.50-0.65 45-85
EXPANSORB® DLG 75-2E 5.43138 PLGA 75/25 ESTER 0.15-0.30 10-25
EXPANSORB® DLG 75-4E 5.43139 PLGA 75/25 ESTER 0.30-0.50 25-60
EXPANSORB® DLG 75-7E 5.43140 PLGA 75/25 ESTER 0.66-0.80 80-115
EXPANSORB® DLG 75-9E 5.43141 PLGA 75/25 ESTER 0.75-1.00 100-160
EXPANSORB® DLG 85-7E 5.43142 PLGA 85/15 ESTER 0.55-0.75 65-95
EXPANSORB® DLG 85-12E 5.45583 PLGA 85/15 ESTER 1.00-1.30 185-210
EXPANSORB® DLG 50-6P 5.43143 PLGA-PEG 50/50 PEG 0.45-0.65 30-60
EXPANSORB® DLG 50-7P 5.43144 PLGA-PEG 50/51 PEG 0.65-0.80 60-85
EXPANSORB® DLG 75-4A 5.45223 PLGA 75/25 COOH 0.30-0.50 25-60