Activated PEGs

Modifications with PEG (polyethylene glycol) not only can significantly improve the physico-chemical properties of therapeutic proteins, but also modify the pharmacokinetics and pharmacodynamics of a drug.

As a global partner, we can supply commercial quantities of high quality functionalized PEGs for use with therapeutic proteins, linkers substances for ADCs and as part of medical devices such as biodegradable hydrogels. therapeutic proteins. Our offerings include a broad range of functionalized PEG products of different molecular weight and activation chemistry., reagents, and process materials for use in investigational products in every phase of clinical development and in commercialized products.

 

Our portfolio of ready-to-use functionalized PEGs

Activation chemistry Target group for conjugation reaction MW [kDa]
Linear MPEGs
-ethylamine -carboxyl 5/20/30
-propylamine
-carboxyl 10/12
-carboxymethyl 
-amine, -hydroxyl 3/20
-ethyl-iodoacetamide 
-thiol 20
-propyl-iodoacetamide 
-thiol 20
-oxyamine 
-aldehyde, -ketone 20/30
-para-nitrophenylcarbonate 
-amine 20/30
-succinimidylcarbonate 
-amine, -hydroxyl 5/20
-succinimidylsuccinate 
-amine, -hydroxyl 5
-succinimidylhexanoate 
-amine, -hydroxyl 20
-ethylthiol
-thiol, -acrylate 5/10/20
Maleimides
-ethylmaleimide -thiol 5
-propylpropionato-maleimide 
-thiol 5/20/30
Aldehydes
-acetaldehyde -amine 20
-propionaldehyde -amine 20
Activation chemistry Target group for conjugation reaction MW [kDa]
Branched PEGs
MPEG2-lysine branching unit for subsequent specific activation According to needs 2x20
MPEG2-40kDa-lys-EP-mal
-thiol 2x20
Activation chemistry Target group for conjugation reaction MW [kDa]
Linear bifunctional PEGs
PEG-bis-ethylamine -carboxyl 2/10
PEG-bis-paranitrophenylcarbonate -amine 5/10/20
PEG-bis-oxyamine -aldehyde, -ketone 5/10/20
PEG-bis-ethyl propionato-maleimide -thiol-linker-thiol- 1/2/10
MAL-PP-PEG-pAld -thilo-linker-amine 10
pAld-PEG-pAld -amine-linker-amine 3.34
Activation chemistry Target group for conjugation reaction MW [kDa]
Multi-arm PEGs
4-arm-acrylate -thiol, -amine 2/15
8-arm-acrylate -thiol, -amine 2
4-arm-propylthiol -thio, -acrylate 2
4-arm-paranitrophenylcarbonate -amine 5/15/20
4-arm-ethylamine -carboxyl 5/10/20
4-arm-succinimidylglutarate -amine, -hydroxyl 10/20
4-arm-succinimidylcarbonate -amine, -hydroxyl 10/20
4-arm-ethyl propionato-maleimide -thiol 20
4-arm-propyl propionato-maleimide -thiol 20
Activation chemistry Target group for conjugation reaction MW [kDa]
Monodisperse PEGS
Backbone chemistry and activation various up to 2kDa

 

Comprehensive PEGylation Services

In addition to offering high-purity raw materials, reagents, and process materials, we provide a range of services to help ensure your success:

  • PEGylation feasibility studies
  • Process development of PEG-drug conjugate manufacturing
  • Development of analytical methods
  • Pilot production of PEG-drug conjugate
  • Development of PEGylated biosimilars