Next-level Downstream Productivity & Versatility – Experience our Natrix® Membrane Chromatography Technology

Natrix® Proprietary Technology

Natrix® Membrane Chromatography Technology – How it works

The NatriFlo® HD-Q membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium (Q) binding groups physically reinforced by an inert fiber web. The interconnected pore structure provides a large surface area for protein binding and high permeability. This unique combination of high-density Q functional group, high definition protein separation and porosity produces a membrane with a very high binding capacity across a wide range of flow rates.

The Natrix® membrane is composed of a porous, functionalized 3-dimensional hydrogel
polymerized within and around a flexible fiber web support
 

Flexible polymeric support web

Flexible polymeric support web physically
reinforces functional hydrogel

Porous functionalized hydrogel

Web is enclosed by and filled with porous functionalized hydrogel,
establishing interconnected macroporous structure

Natrix® Advective Chromatography

NatriFlo® HD-Q Membrane Adsorber for Single-use per Batch Biomolecule Purification

A high capacity, high throughput strong anion exchange membrane adsorber designed to purify biomolecules in operating conditions. The unique NatriFlo® HD-Q membrane contains a high density of quaternary amine ligands that are directly polymerized within the porous membrane scaffold. The interconnected pore structure and high ligand density enables fast flow rates with impressive throughput to extremely high loads while maintaining excellent impurity reduction. The NatriFlo® HD-Q membrane design delivers improvements in productivity, flexibility, and process robustness for any bioprocess design.

NatriFlo® HD-Q Membrane Adsorber for Single-use per Batch Biomolecule Purification

Product Benefits

  • Best-in-class HCP, DNA and viral clearance, even with the most challenging feed streams
  • Salt and pH tolerance with strong anion exchange (Q) chemistry even in phosphate buffer systems
  • High capacity final polishing purification with extreme protein throughput (>10 kg/L)
  • Simple, low-cost polishing operations in a single-use format
Ordering Information
 
Product No. Description
NXF-01 NatriFlo® HD-Q Recon Mini
NXF-10 NatriFlo® HD-Q Pilot
NXF-20 NatriFlo® HD-Q Process 150
NXF-50 NatriFlo® HD-Q Process 600


Related Links

Webinar: High Productivity Membrane Chromatography: Enabling the Next Generation Bioprocessing Paradigm

WebinarDownstream Process Intensification for Virus Purification Using Membrane Chromatography

Chrom Talk on LinkedIn

BioContinuum