Publications for Muse® Cell Analyzer and Assays

 August 2018

 

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells   
Original Research Article
Free Radical Biology and Medicine, Available online 27 July 2018, Pages
Claudia Sticozzi, Alessandra Pecorelli, Arianna Romani, Giuseppe Belmonte, Franco Cervellati, Emanuela Maioli, Mary Ann Lila, Carlo Cervellati, Giuseppe Valacchi
MicroRNA-101a suppresses fibrotic programming in isolated cardiac fibroblasts and in vivo fibrosis following trans-aortic constriction   
Original Research Article
Journal of Molecular and Cellular Cardiology, Volume 121, August 2018, Pages 266-276
Yue Zhou, Thiam Chien Shiok, Arthur Mark Richards, Peipei Wang
Indolyl-chalcone derivatives induce hepatocellular carcinoma cells apoptosis through oxidative stress related mitochondrial pathway in vitro and in vivo   
Original Research Article
Chemico-Biological Interactions, Volume 293, 25 September 2018, Pages 61-69
Xinrui Zhang, Mengya Wang, Shanshan Teng, Di Wang, Xin Li, Xiaofeng Wang, Weiwei Liao, Di Wang
miR-590–3p inhibits proliferation and promotes apoptosis by targeting activating transcription factor 3 in human breast cancer cells   
Original Research Article
Biochimie, Volume 154, November 2018, Pages 10-18
M. Rohini, M. Gokulnath, P.J. Miranda, N. Selvamurugan

 

 July 2018

 

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress   
Cell Metabolism, Available online 5 July 2018, Pages
Kyung Hwa Kim, Jyung Mean Son, Bérénice A. Benayoun, Changhan Lee

Graphical Abstract

 

Chronic toxicity of nanodiamonds can disturb development and reproduction of Acheta domesticus L   
Original Research Article
Environmental Research, Volume 166, October 2018, Pages 602-609
Julia Karpeta-Kaczmarek, Andrzej Kędziorski, Maria A. Augustyniak-Jabłokow, Marta Dziewięcka, Maria Augustyniak

Graphical abstract

 

Krill oil protects PC12 cells against methamphetamine induced neurotoxicity by inhibiting apoptotic response and oxidative stress   
Original Research Article
Nutrition Research, Available online 17 July 2018, Pages
Qi Xiong, Qin Ru, Xiang Tian, Mei Zhou, Lin Chen, Yi Li, Chaoying Li  

In vitro combinatorial anti-proliferative and immunosuppressive effects of Brucea javanica extract with CX-4945 and imatinib in human T-cell acute lymphoblastic leukemia cells   
Original Research Article
Biomedicine & Pharmacotherapy, Volume 106, October 2018, Pages 403-410
Jung-Il Jung, Se Young Kim, Kyeong-Yong Park, Kongmany Sydara, Sang Woo Lee, Soon Ae Kim, Jiyeon Kim

Graphical abstract

 

 June 2018

 

Eucalyptus microcorys leaf extract derived HPLC-fraction reduces the viability of MIA PaCa-2 cells by inducing apoptosis and arresting cell cycle
Original Research Article
Biomedicine & Pharmacotherapy, Volume 105, September 2018, Pages 449-460
Deep Jyoti Bhuyan, Quan V. Vuong, Danielle R. Bond, Anita C. Chalmers, Michael C. Bowyer, Christopher J. Scarlett

Graphical abstract

Biogenic synthesis of ZnO nanoparticles using Monsonia burkeana for use in photocatalytic, antibacterial and anticancer applications
Original Research Article
Ceramics International, Available online 19 June 2018, Pages
N.M. Ngoepe, Z. Mbita, M. Mathipa, N. Mketo, B. Ntsendwana, N.C. Hintsho-Mbita
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA
Original Research Article
European Journal of Medicinal Chemistry, Volume 155, 15 July 2018, Pages 609-622
Veysel T. Yilmaz, Ceyda Icsel, Omer R. Turgut, Muhittin Aygun, Merve Erkisa, Mehmet H. Turkdemir, Engin Ulukaya

Graphical abstract

 

 May 2018

 

Polymorphonuclear neutrophil integrity and functionality are preserved when exposed to saliva
Original Research Article
Archives of Oral Biology, Volume 92, August 2018, Pages 68-74
Patrick Rijkschroeff, Sabrina T.G. Gunput, Antoon J.M. Ligtenberg, Enno C.I. Veerman, Bruno G. Loos, Elena A. Nicu
Protective effects of silk lutein extract from Bombyx mori cocoons on β-Amyloid peptide-induced apoptosis in PC12 cells
Original Research Article
Biomedicine & Pharmacotherapy, Volume 103, July 2018, Pages 582-587
Nongnuch Singhrang, Chainarong Tocharus, Sarinthorn Thummayot, Manote Sutheerawattananonda, Jiraporn Tocharus

Graphical abstract

Manipulation of a glycolytic regulator alters growth and carbon partitioning in the marine diatom Thalassiosira pseudonana
Original Research Article
Algal Research, Volume 32, June 2018, Pages 250-258
Raffaela Abbriano, Nurcan Vardar, Daniel Yee, Mark Hildebrand
Reduced fecundity and cellular changes in Acheta domesticus after multigenerational exposure to graphene oxide nanoparticles in food
Original Research Article
Science of The Total Environment, Volume 635, 1 September 2018, Pages 947-955
Marta Dziewięcka, Piotr Witas, Julia Karpeta-Kaczmarek, Jolanta Kwaśniewska, Barbara Flasz, Katarzyna Balin, Maria Augustyniak

Graphical abstract

Solid lipid nanoparticles: Reversal of tamoxifen resistance in breast cancer
Original Research Article
European Journal of Pharmaceutical Sciences, Volume 120, 30 July 2018, Pages 73-88
Gamze Guney Eskiler, Gulsah Cecener, Gokhan Dikmen, Unal Egeli, Berrin Tunca

Graphical abstract
Tam-SLNs could potentially overcome Tam-resistance by inducing apoptosis in breast cancer.Unlabelled Image

1,2,3,4,6-Penta-O-galloyl-β-d-glucose suppresses colon cancer through induction of tumor suppressor   
Bioorganic & Medicinal Chemistry Letters, Available online 14 May 2018, Pages
Sang Hee Kawk, Ye Rim Kang, Yoon Hee Kim

Graphical abstract
 

A new chimeric triple reporter fusion protein as a tool for in vitro and in vivo multimodal imaging to monitor the development of African trypanosomes and Leishmania parasites
Original Research Article
Infection, Genetics and Evolution, Available online 25 April 2018, Pages
Estefania Calvo-Alvarez, Christelle Cren-Travaillé, Aline Crouzols, Brice Rotureau
DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells
Original Research Article
Gene, Volume 665, 30 July 2018, Pages 67-73
Diannan Xu, Meiling Du, Jun Zhang, Panpan Xiong, Wenshuai Li, Huilu Zhang, Wujun Xiong, Fei Liu, Jie Liu
Influence and mechanism of Angiotensin 1-7 on biological properties of normal prostate epithelial cells   
Biochemical and Biophysical Research Communications, Volume 502, Issue 1, 7 July 2018, Pages 152-159
Kamila Domińska, Piotr Okła, Karolina Kowalska, Dominika Ewa Habrowska-Górczyńska, Kinga Anna Urbanek, Tomasz Ochędalski, Agnieszka Wanda Piastowska-Ciesielska
ID2 protects retinal pigment epithelium cells from oxidative damage through p-ERK1/2/ID2/NRF2
Original Research Article
Archives of Biochemistry and Biophysics, Volume 650, 15 July 2018, Pages 1-13
Yuting Fan, Zixin Huang, Chongde Long, Jie Ning, Han Zhang, Xielan Kuang, Qingjiong Zhang, Huangxuan Shen
Polymorphonuclear neutrophil integrity and functionality are preserved when exposed to saliva
Original Research Article
Archives of Oral Biology, Volume 92, August 2018, Pages 68-74
Patrick Rijkschroeff, Sabrina T.G. Gunput, Antoon J.M. Ligtenberg, Enno C.I. Veerman, Bruno G. Loos, Elena A. Nicu
Sustained release of chrysin from chitosan-based scaffolds promotes mesenchymal stem cell proliferation and osteoblast differentiation
Original Research Article
Carbohydrate Polymers, Volume 195, 1 September 2018, Pages 356-367
A. Haritha Menon, S. Preethi Soundarya, V. Sanjay, S. Viji Chandran, K. Balagangadharan, N. Selvamurugan
Effect of antiaggregants on the in vitro viability, cell count and stability of abalone (Haliotis iris) haemocytes
Original Research Article
Fish & Shellfish Immunology
, Volume 78, July 2018, Pages 131-139
Roffi Grandiosa, Mai-Louise Bouwman, Tim Young, Fabrice Mérien, Andrea C. Alfaro
HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production Research article
Redox Biology
, Volume 15, May 2018, Pages 97-108
Rawan El-Amine, Diego Germini, Vlada V. Zakharova, Tatyana Tsfasman, Yegor S. Vassetzky
Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes
Research article
Food and Chemical Toxicology
, Volume 115, May 2018, Pages 1-12
Dominika Malinska, Jędrzej Szymański, Paulina Patalas-Krawczyk, Bernadeta Michalska, Mariusz R. Wieckowski
MiR-615 inhibits cell proliferation, migration and invasion by targeting EGFR in human glioblastoma
Short communication
Biochemical and Biophysical Research Communications

Volume 499, Issue 3, 15 May 2018, Pages 719-726

Yanwei Ji, Qingshan Sun, Jianbin Zhang, Haoran Hu

 

 April 2018

 

Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription
Original Research Article
Redox Biology, Available online 3 April 2018, Pages
Steven M. Pennington, Paula R. Klutho, Litao Xie, Kim Broadhurst, Olha M. Koval, Michael L. McCormick, Douglas R. Spitz, Isabella M. Grumbach

Graphical abstract

MiR-615 inhibits cell proliferation, migration and invasion by targeting EGFR in human glioblastoma
Biochemical and Biophysical Research Communications, Available online 3 April 2018, Pages
Yanwei Ji, Qingshan Sun, Jianbin Zhang, Haoran Hu
ZH-1 enhances the anticancer activity of gemcitabine via deoxyribonucleotide synthesis and apoptotic pathway against A549 cells
Original Research Article
Food and Chemical Toxicology, Available online 10 April 2018, Pages
Jianru Guo, Yan Li, Christopher Wai Kei Lam, Caiyun Wang, Meicun Yao, Wei Zhang
Effect of antiaggregants on the in vitro viability, cell count and stability of abalone (Haliotis iris) haemocytes
Original Research Article
Fish & Shellfish Immunology, Available online 21 April 2018, Pages
Roffi Grandiosa, Mai-Louise Bouwman, Tim Young, Fabrice Mérien, Andrea C. Alfaro
Pharmacological effect of prohibited combination pair Panax ginseng and Veratrum nigrum on colorectal metastasis in vitro and in vivo
Original Research Article
Journal of Ethnopharmacology, Available online 28 March 2018, Pages
Ji-Ye Kee, Yo-Han Han, Jeong-Geon Mun, Jae-Young Um, Seung-Heon Hong

Graphical abstract

Phytol isolated from watermelon (Citrullus lanatus) sprouts induces cell death in human T-lymphoid cell line Jurkat cells via S-phase cell cycle arrest
Original Research Article
Food and Chemical Toxicology, Available online 30 March 2018, Pages
Tomohiro Itoh, Akito Ono, Kaori Kawaguchi, Sayaka Teraoka, Mayo Harada, Keitaro Sumi, Masashi Ando, Yasuyuki Tsukamasa, Masayuki Ninomiya, Mamoru Koketsu, Toshiharu Hashizume

Graphical abstract

 

Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms
Original Research Article
Environmental Pollution, Volume 239, August 2018, Pages 300-307
Wenting Song, Qian S. Liu, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou, Guibin Jiang

Graphical abstract

 

 March 2018

 

The inhibitory potential of broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation
Original Research Article
Phytomedicine, Available online 19 March 2018, Pages

See-Hyoung Park, Jongsung Lee, Jong Cheol Shon, Nguyen Minh Phuc, Jun Goo Jee, Kwang-Hyeon Liu

Graphical abstract

 

Fruit waste (peel) as bio-reductant to synthesize silver nanoparticles with antimicrobial, antioxidant and cytotoxic activities
Original Research Article
Journal of Applied Biomedicine, Available online 12 March 2018, Pages
Annu, Shakeel Ahmed, Gurpreet Kaur, Praveen Sharma, Sandeep Singh, Saiqa Ikram

Graphical abstract

 

Synthesis and Biological Evaluation of Pyrimidine Bridged Combretastatin Derivatives as Potential Anticancer Agents and Mechanistic Studies
Original Research Article
Bioorganic Chemistry, Available online 28 February 2018, Pages
Bhupinder Kumar, Praveen Sharma, Vivek Prakash Gupta, Madhu Khullar, Sandeep Singh, Nilambra Dogra, Vinod Kumar

Graphical abstract
Pyrimidine bridged combretastatin derivatives as anticancer agents

 

The inhibitory effect of Cordycepin on the proliferation of cisplatin-resistant A549 lung cancer cells
Biochemical and Biophysical Research Communications, Available online 26 February 2018, Pages
Seong Hyeok Cho, In-Cheol Kang

 

 February 2018

 

Task-shifting of CD4 T cell count monitoring by the touchscreen-based Muse™ Auto CD4/CD4% single-platform system for CD4 T cell numeration: Implication for decentralization in resource-constrained settings
Journal of Immunological Methods, Available online 2 February 2018, Pages
André Kouabosso, Christian Diamant Mossoro-Kpinde, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Marcel Mbeko Simaleko, Gérard Grésenguet, Laurent Bélec
Preclinical evaluation of the mono-PEGylated recombinant human interleukin-11 in cynomolgus monkeys
Original Research Article
Toxicology and Applied Pharmacology, Volume 342, 1 March 2018, Pages 39-49

Kuo-Ming Yu, Johnson Yiu-Nam Lau, Manson Fok, Yuk-Keung Yeung, Siu-Ping Fok, Suxing Zhang, Peizhen Ye, Kezhi Zhang, Xiaobo Li, Juan Li, Qin Xu, Wing-Tak Wong, Qui-Lim Choo
Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson’s disease model
Original Research Article
Toxicology Letters, Available online 16 February 2018, Pages

Xiao Xu Bai, Li Gu, Hui Min Yang, Shao Song Xi, Ning Xia, Song Zhang, Hong Zhang

Graphical abstract

 

Assessment of mitochondrial function following short- and long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product and reference cigarettes
Original Research Article
Food and Chemical Toxicology, Available online 13 February 2018, Pages

Dominika Malińska, Jędrzej Szymański, Paulina Patalas-Krawczyk, Bernadeta Michalska, Aleksandra Wojtala, Monika Prill, Małgorzata Partyka, Karolina Drabik, Jarosław Walczak, Alain Sewer, Stephanie Johne, Karsta Luettich, Manuel C. Peitsch, Julia Hoeng, Jerzy Duszyński, Joanna Szczepanowska, Marco van der Toorn, Mariusz R. Wieckowski
Characterization of the complexation phenomenon and biological activity in vitro of polyplexes based on Tetronic T901 and DNA.
Original Research Article
Journal of Colloid and Interface Science, Available online 17 February 2018, Pages

Adriana Cambón, Eva Villar-Alvarez, Manuel Alatorre-Meda, Alberto Pardo, Baltazar Hiram, Silvia Barbosa, Pablo Taboada, Víctor Mosquera

Graphical abstract

 

Bavachin induces the apoptosis of multiple myeloma cell lines by inhibiting the activation of nuclear factor kappa B and signal transducer and activator of transcription 3
Original Research Article
Biomedicine & Pharmacotherapy, Volume 100, April 2018, Pages 486-494

Tomoya Takeda, Masanobu Tsubaki, Yoshika Tomonari, Keishi Kawashima, Tatsuki Itoh, Motohiro Imano, Takao Satou, Shozo Nishida

Label-free optical biosensor for real-time monitoringthe cytotoxicity of xenobiotics: A proof of principle study on glyphosate
Original Research Article
Journal of Hazardous Materials, Available online 23 February 2018, Pages

Eniko Farkas, Andras Szekacs, Boglarka Kovacs, Marianna Olah, Robert Horvath, Inna Szekacs

Graphical abstract

Cryopreserved rainbow trout semen can be used for the fertilization of up to 8000 eggs in a single application   Aquaculture, Available online 20 February 2018, Pages
Sylwia Judycka, Joanna Nynca, Ewa Liszewska, Stefan Dobosz, Mariola Słowińska, Rafał Różyński, Andrzej Ciereszko
Sulfated polysaccharides from Padina tetrastromatica induce apoptosis in HeLa cells through ROS triggered mitochondrial pathway
Original Research Article
Process Biochemistry, Available online 19 February 2018, Pages

Geena Mariya Jose, R. Mahadevan, G. Muraleedhara Kurup

Graphical abstract

 

 

 January 2018

 

Gamma-linolenic acid ameliorates Aβ-induced neuroinflammation through NF-κB and MAPK signalling pathways
Original Research Article
Journal of Functional Foods, Volume 42, March 2018, Pages 30-37
Kumju Youn, Seonah Lee, Mira Jun

Graphical abstract

 

The AGP-PPARγ axis promotes oxidative stress and diabetic endothelial cell dysfunction
Original Research Article
Molecular and Cellular Endocrinology, Available online 20 January 2018, Pages

Ryoko Tsukahara, Hisao Haniu, Yoshikazu Matsuda, Tamotsu Tsukahara
microRNA-219 reduces viral load and pathologic changes in Theiler’s virus-induced demyelinating disease
Original Research Article
Molecular Therapy, Available online 17 January 2018, Pages

Ana Lis Moyano, Jeffrey Steplowski, Haibo Wang, Kyung-No Son, Diana I. Rapolti, Jeffrey Marshall, Vince Elackattu, Michael S. Marshall, Amy K. Hebert, Cory Reiter, Viviana Ulloa, Katarzyna C. Pituch, Maria I. Givogri, Q.Richard Lu, Howard L. Lipton, Ernesto R. Bongarzone

Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation
Review Article
European Journal of Medicinal Chemistry, Available online 31 January 2018, Pages

Maud Bollenbach, Eric Salvat, François Daubeuf, Patrick Wagner, Ipek Yalcin, Muris Humo, Baptiste Letellier, Léa J. Becker, Frédéric Bihel, Jean-Jacques Bourguignon, Pascal Villa, Adeline Obrecht, Nelly Frossard, Michel Barrot, Martine Schmitt

Graphical abstract

Double silencing of relevant genes suggests the existence of the direct link between DNA replication/repair and central carbon metabolism in human fibroblasts
Original Research Article
Gene, Available online 31 January 2018, Pages

Aneta Wieczorek, Karolina Fornalewicz, Łukasz Mocarski, Robert Łyżeń, Grzegorz Węgrzyn

 

 December 2017

 

Synergistic therapeutic effect of diethylstilbestrol and CX-4945 in human acute T-lymphocytic leukemia cells
Original Research Article
Biomedicine & Pharmacotherapy, Volume 98, February 2018, Pages 357-363

Jung-Il Jung, Kyeong-Yong Park, Soon Ae Kim, Jiyeon Kim

Graphical abstract

 

Biological evaluation of indolizine-chalcone hybrids as new anticancer agents
European Journal of Medicinal Chemistry, Available online 19 December 2017, Pages

Sujin Park, Eun Hye Kim, Jinwoo Kim, Seong Hwan Kim, Ikyon Kim

Graphical abstract

 

Optimal sperm concentration in straws and final glucose concentration in extender are crucial for improving the cryopreservation protocol of salmonid spermatozoa
Original Research Article
Aquaculture, Volume 486, 3 February 2018, Pages 90-97
Sylwia Judycka, Joanna Nynca, Ewa Liszewska, Stefan Dobosz, Joanna Grudniewska, Andrzej Ciereszko
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
Original Research Article
Chemico-Biological Interactions, Available online 7 December 2017, Pages
Nazlıhan Aztopal, Merve Erkisa, Elif Erturk, Engin Ulukaya, Asuman Hatice Tokullugil, Ferda Ari

Graphical abstract

 

Inhibition of the mitochondrial calcium uniporter prevents IL-13 and allergen-mediated airway epithelial apoptosis and loss of barrier function   
Original Research Article
Experimental Cell Research, Available online 8 December 2017, Pages
Sara C Sebag, Olha M Koval, John D Paschke, Christopher J Winters, Alejandro P Comellas, Isabella M Grumbach

Graphical abstract

 

ABT737 induces mitochondrial pathway apoptosis and mitophagy by regulating DRP1-dependent mitochondrial fission in human ovarian cancer cells
Original Research Article
Biomedicine & Pharmacotherapy, Volume 96, December 2017, Pages 22-29
Yang Yu, Lu Xu, Ling Qi, Chunyan Wang, Na Xu, Shibing Liu, Songyan Li, Hongyan Tian, Weimin Liu, Ye Xu, Zhixin Li
HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production
Original Research Article
Redox Biology, Available online 2 December 2017, Pages
Rawan El-Amine, Diego Germini, Vlada V. Zakharova, Tatyana Tsfasman, Eugene V. Sheval, Ruy A.N. Louzada, Corinne Dupuy, Chrystèle Bilhou-Nabera, Aline Hamade, Fadia Najjar, Eric Oksenhendler, Marс Lipinski, Boris V. Chernyak, Yegor S. Vassetzky

Graphical abstract

 

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Original Research Article
Pharmacological Research, Available online 2 December 2017, Pages
Buse Cevatemre, Merve Erkısa, Nazlihan Aztopal, Didem Karakas, Pınar Alper, Chrisiida Tsimplouli, Evangelia Sereti, Konstantinos Dimas, Elif I. Ikitimur Armutak, Ebru Gurel Gurevin, Ayca Uvez, Mattia Mori, Simone Berardozzi, Cinzia Ingallina, Ilaria D’Acquarica, Bruno Botta, Bulent Ozpolat, Engin Ulukaya

Graphical abstract

 

 

 November 2017

 

A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells   
Original Research Article
Molecular and Cellular Neuroscience, Available online 9 November 2017, Pages
Rawaa S. Al-Mayyahi, Luke D. Sterio, Joanne B. Connolly, Christopher F. Adams, Wa'il A. Al-Tumah, Jon Sen, Richard D. Emes, Sarah R. Hart, Divya M. Chari
Didodecyldimethylammonium bromide (DMAB) stabilized poly(lactic-co-glycolic acid) (PLGA) nanoparticles: Uptake and cytotoxic potential in Caco-2 cells   
Original Research Article
Journal of Drug Delivery Science and Technology, Available online 6 November 2017, Pages
R. Gossmann, S. Spek, K. Langer, D. Mulac

Graphical abstract

 

Effect of the FE2 + chelation by 2,2′-dipyridyl in the doxorubicin-induced lethality in breast tumor cell lines
Original Research Article
Life Sciences, Available online 24 November 2017, Pages
Jéssica R. Bernardes, Caroline C. de Faria, Iris S. Andrade, Andrea Claudia Freitas Ferreira, Denise P. Carvalho, Alvaro C. Leitão, Tatiana A.M. de Alencar, Rodrigo S. Fortunato
Antagonistic effect of oxytocin and tacrolimus combination on adipose tissue – derived mesenchymal stem cells antagonistic effect of oxytocin and tacrolimus: Antagonistic effect of oxytocin and tacrolimus
Original Research Article
Biomedicine & Pharmacotherapy, Volume 97, January 2018, Pages 1173-1181
Gozde Sir, Bakiye Goker Bagca, Gurkan Yigitturk, Turker Cavusoglu, Cigir Biray Avci, Cumhur Gunduz, Yigit Uyanikgil
 

 

 October 2017

 

Associations between immunological function and memory recall in healthy adults
Original Research Article
Brain and Cognition, Volume 119, December 2017, Pages 39-44
Grace Y. Wang, Tamasin Taylor, Alexander Sumich, Fabrice Merien, Robert Borotkanics, Wendy Wrapson, Chris Krägeloh, Richard J. Siegert

 

Synthesis and biological evaluation of novel coumarin-chalcone derivatives containing urea moiety as potential anticancer agents
Original Research Article
Arabian Journal of Chemistry, Available online 7 October 2017, Pages
Belma Zengin Kurt, Nur Ozten Kandas, Aydan Dag, Fatih Sonmez, Mustafa Kucukislamoglu

 

Kinase-independent role of nuclear RIPK1 in regulating parthanatos through physical interaction with PARP1 upon oxidative stress
Original Research Article
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Available online 7 October 2017, Pages
Ki-Hong Jang, Taeik Jang, Eunji Son, Soonjin Choi, Eunhee Kim

 

HSP90 inhibitor (NVP-AUY922) enhances the anti-cancer effect of BCL-2 inhibitor (ABT-737) in Small cell lung cancer expressing BCL-2 
Original Research Article
Cancer Letters, Available online 4 October 2017, Pages

Hannah Yang, Mi-Hee Lee, Intae Park, Hanwool Jeon, Junyoung Choi, Seyoung Seo, Sang-We Kim, Gou Young Koh, Kang-Seo Park, Dae Ho Lee
Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy
Original Research Article
Toxicology in Vitro, Available online 4 October 2017, Pages

Nipha Chaicharoenaudomrung, Thiranut Jaroonwitchawan, Parinya Noisa

Graphical abstract

In vitro genotoxicity and cytotoxicity of polydopamine-coated magnetic nanostructures
Original Research Article
Toxicology in Vitro, Volume 44, October 2017, Pages 256-265

Anna Woźniak, Magdalena Walawender, Dominika Tempka, Emerson Coy, Karol Załęski, Bartosz F. Grześkowiak, Radosław Mrówczyński
Mitochondrial dysfunction and inflammatory response in the cytotoxicity of NR8383 macrophages induced by fine particulate matter
Original Research Article
Environmental Toxicology and Pharmacology, Volume 55, October 2017, Pages 1-7

Qi Xiong, Qin Ru, Lin Chen, Xiang Tian, Chaoying Li
Antitumor potential of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles in human bladder cancer cells
Original Research Article
Biomedicine & Pharmacotherapy, Volume 94, October 2017, Pages 37-46
Josiane Weber Tessmann, Julieti Buss, Karine Rech Begnini, Lucas Moraes Berneira, Favero Reisdorfer Paula, Claudio Martin Pereira de Pereira, Tiago Collares, Fabiana Kömmling Seixas
High expression of VRK1 is related to poor prognosis in glioma
Original Research Article
Pathology - Research and Practice, Available online 18 October 2017, Pages
Zhiyun Ben, Leilei Gong, Yuhua Qiu
Non-steroidal anti-inflammatory drugs are safe with respect to the transcriptome of human dermal fibroblasts
Original Research Article
European Journal of Pharmacology, Available online 24 October 2017, Pages

Paweł Mozolewski, Joanna Jakóbkiewicz-Banecka, Grzegorz Węgrzyn, Bogdan Banecki, Magdalena Gabig-Cimińska
The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia
Original Research Article
Biochimica et Biophysica Acta (BBA) - Bioenergetics, Available online 31 October 2017, Pages

G. Sgarbi, S. Barbato, A. Costanzini, G. Solaini, A. Baracca

 

 

 September 2017

 

Tuning the structure of aminoferrocene-based anticancer prodrugs to prevent their aggregation in aqueous solution
Original Research Article
Journal of Inorganic Biochemistry, Available online 15 September 2017, Pages

Steffen Daum, Svetlana Babiy, Helen Konovalova, Walter Hofer, Alexander Shtemenko, Natalia Shtemenko, Christina Janko, Christoph Alexiou, Andriy Mokhir

Graphical abstract
Substitution of N-benzyl for an N-propargyl residue in the anticancer prodrug 4-(N-benzyl-N-ferrocenylaminocarbonyloxymethyl)phenylboronic acid pinacol ester led to reduction of its lipophilicity, improvement of its water solubility, decrease of its propensity towards aggregation and dramatic increase of its ROS-generating properties without any negative effect on its anticancer activity.
Globularifolin exerts anticancer effects on glioma U87 cells through inhibition of Akt/mTOR and MEK/ERK signaling pathways in vitro and inhibits tumor growth in vivo 
Original Research Article
Biochimie, Available online 11 September 2017, Pages

Yunhu Yu, Xiaohong Fu, Qishan Ran, Kaihua Yang, Yuanchao Wen, Hang Li, Fei Wang

Graphical abstract
Image 1

Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival 
Original Research Article
Molecular Immunology, Volume 91, November 2017, Pages 8-16

Lou-Ella M.M. Alexander, January Watters, Jessica A. Reusch, Michelle Maurin, Brook S. Nepon-Sixt, Katerina Vrzalikova, Mark G. Alexandrow, Paul G. Murray, Kenneth L. Wright
Harvesting of Dunaliella salina by membrane filtration at pilot scale   
Original Research Article
Separation and Purification Technology, Available online 1 September 2017, Pages

Joana Monte, Marta Sá, Cláudia F. Galinha, Luís Costa, Herre Hoekstra, Carla Brazinha, João G. Crespo
Silencing of the pentose phosphate pathway genes influences DNA replication in human fibroblasts  
Gene, Available online 5 September 2017, Pages

Karolina Fornalewicz, Aneta Wieczorek, Grzegorz Węgrzyn, Robert Łyżeń

 

 August 2017

 

Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression   
Original Research Article
Redox Biology, Available online 18 August 2017, Pages
Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Ewelina Semik, Tomasz Zabek, Maciej Wnuk
Mitochondrial Dysfunction and Inflammatory Response in the Cytotoxicity of NR8383 Macrophages Induced by Fine Particulate Matter   
Original Research Article
Environmental Toxicology and Pharmacology, Available online 29 July 2017, Pages
Qi Xiong, Qin Ru, Lin Chen, Xiang Tian, Chaoying Li

 

 July 2017

 

Antitumor potential of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-1H-pyrazoles in human bladder cancer cells   
Original Research Article
Biomedicine & Pharmacotherapy, Volume 94, October 2017, Pages 37-46
Josiane Weber Tessmann, Julieti Buss, Karine Rech Begnini, Lucas Moraes Berneira, Favero Reisdorfer Paula, Claudio Martin Pereira de Pereira, Tiago Collares, Fabiana Kömmling Seixas
In vitro genotoxicity and cytotoxicity of polydopamine-coated magnetic nanostructures   
Original Research Article
Toxicology in Vitro, Volume 44, October 2017, Pages 256-265
Anna Woźniak, Magdalena Walawender, Dominika Tempka, Emerson Coy, Karol Załęski, Bartosz F. Grześkowiak, Radosław Mrówczyński
In vitro studies of the anticancer action of Tectaria cicutaria in human cancer cell lines: G0/G1 p53-associated cell cycle arrest-Part I   
Original Research Article
Journal of Traditional and Complementary Medicine, Available online 26 July 2017, Pages
Preeti Gajendra Karade, Namdeo Ramhari Jadhav

Graphical abstract


Aptamer-Based Electrochemical Biosensor for Highly Sensitive and Selective Malaria Detection with Adjustable Dynamic Response Range and Reusability   
Original Research Article
Sensors and Actuators B: Chemical, Available online 21 July 2017, Pages
Gabriela Figueroa Miranda, Lingyan Feng, Simon Chi-Chin Shiu, Roderick Marshall Dirkzwager, Yee-Wai Cheung, Julian Alexander Tanner, Michael Josef Schöning, Andreas Offenhäusser, Dirk Mayer
The nitroxide 4-methoxy TEMPO inhibits neutrophil-stimulated kinase activation in H9c2 cardiomyocytes   
Original Research Article
Archives of Biochemistry and Biophysics, Available online 5 July 2017, Pages
B. Chami, G. Jeong, A. Varda, A.-M. Maw, H.-B. Kim, G.M. Fong, M. Simone, B.S. Rayner, X.-S. Wang, J.M. Dennis, P.K. Witting

 

 May 2017

 

2D Fluorescence spectroscopy for monitoring Dunaliella salina concentration and integrity during membrane harvesting
Original Research Article
Algal Research, Volume 24, Part A, June 2017, Pages 325-332
Marta Sá, Joana Monte, Carla Brazinha, Claudia F Galinha, João G Crespo
Klotho protects human monocytes from LPS-induced immune impairment associated with immunosenescent-like phenotype 
Original Research Article
Molecular and Cellular Endocrinology, Available online 3 May 2017, Pages
Jennifer Mytych, Maria Romerowicz-Misielak, Marek Koziorowski
Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson’s disease on liver cancer
Original Research Article
Pharmacological Research, Available online 26 April 2017, Pages
Shao-Song Xi, Xiao-Xu Bai, Li Gu, Li-Hui Bao, Hui-Min Yang, Wei An, Xiao-Min Wang, Hong Zhang
Melicope ptelefolia leaf extracts exhibit antioxidant activity and exert anti-proliferative effect with apoptosis induction on four different cancer cell lines

 

BMC Complementary and Alternative Medicine

Mohammad Faujul Kabir, Johari Mohd Ali, Mitra Abolmaesoomi and Onn Haji Hashim

Melicope ptelefolia is a well-known herb in a number of Asian countries. It is often used as vegetable salad and traditional medicine to address various ailments. However, not many studies have been currently done to evaluate the medicinal benefits of M. ptelefolia (MP). The present study reports antioxidant, anti-proliferative, and apoptosis induction activities of MP leaf extracts.

Young MP leaves were dried, powdered and extracted sequentially using hexane (HX), ethyl acetate (EA), methanol (MeOH) and water (W). Antioxidant activity was evaluated using ferric reducing antioxidant power (FRAP), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radicals scavenging and cellular antioxidant activity (CAA) assays. Anti-proliferative activity was evaluated through cell viability assay, using the following four human cancer cell lines: breast (HCC1937, MDA-MB-231), colorectal (HCT116) and liver (HepG2). The anti-proliferative activity was further confirmed through cell cycle and apoptosis assays, including annexin-V/7-aminoactinomycin D staining and measurements of caspase enzymes activation and inhibition.

Overall, MP-HX extract exhibited the highest antioxidant potential, with IC50 values of 267.73 ± 5.58 and 327.40 ± 3.80 μg/mL for ABTS and DPPH radical-scavenging assays, respectively. MP-HX demonstrated the highest CAA activity in Hs27 cells, with EC50 of 11.30 ± 0.68 μg/mL, while MP-EA showed EC50 value of 37.32 ± 0.68 μg/mL. MP-HX and MP-EA showed promising anti-proliferative activity towards the four cancer cell lines, with IC50 values that were mostly below 100 μg/mL. MP-HX showed the most notable anti-proliferative activity against MDA-MB-231 (IC50 = 57.81 ± 3.49 μg/mL) and HCT116 (IC50 = 58.04 ± 0.96 μg/mL) while MP-EA showed strongest anti-proliferative activity in HCT116 (IC50 = 64.69 ± 0.72 μg/mL). The anticancer potential of MP-HX and MP-EA were also demonstrated by their ability to induce caspase-dependent apoptotic cell death in all of the cancer cell lines tested. Cell cycle analysis suggested that both the MP-HX and MP-EA extracts were able to disrupt the cell cycle in most of the cancer cell lines.

MP-HX and MP-EA extracts demonstrated notable antioxidant, anti-proliferative, apoptosis induction and cancer cell cycle inhibition activities. These findings reflect the promising potentials of MP to be a source of novel phytochemical(s) with health promoting benefits that are also valuable for nutraceutical industry and cancer therapy.

 

 April 2017

 

Design, synthesis, and identification of a novel napthalamide-isoselenocyanate compound NISC-6 as a dual Topoisomerase-IIα and Akt pathway inhibitor, and evaluation of its anti-melanoma activity   
Original Research Article
European Journal of Medicinal Chemistry, Available online 21 April 2017, Pages
Deepkamal N. Karelia, Ugir Hossain Sk, Parvesh Singh, A.S. Prakasha Gowda, Manoj K. Pandey, Srinivasa R. Ramisetti, Shantu Amin, Arun K. Sharma

Graphical abstract 

 

 

 March 2017

 

Efficient and reproducible in vitro regeneration of Solanum lycopersicum and assessment genetic uniformity using flow cytometry and SPAR methods   
Original Research Article
Saudi Journal of Biological Sciences, Available online 16 March 2017, Pages
Mohammad Faisal, Abdulrahman A. Alatar, Eslam M. Abdel-Salam, Tomas Canto, Quaiser Saquib, Saad B. Javed, Mohamed A. El-Sheikh, Abdulaziz A. Al-Khedhairy
High resolution UHPLC-MS characterization and isolation of main compounds from the antioxidant medicinal plant Parastrephia lucida (Meyen)   
Original Research Article
Saudi Pharmaceutical Journal, Available online 14 March 2017, Pages



 

 

Carlos Echiburu-Chau, Leyla Pastén, Claudio Parra, Jorge Bórquez, Andrei Mocan, Mario J. Simirgiotis

Graphical abstract

 

Propagation of Brazilian Zika virus strains in static and suspension cultures using Vero and BHK cells   
Original Research Article
Vaccine, Available online 23 March 2017, Pages
Alexander Nikolay, Leda R. Castilho, Udo Reichl, Yvonne Genzel
Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells   
Biochemical and Biophysical Research Communications, Available online 18 March 2017, Pages
Theetat Ruangjaroon, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, N. Monique Paricharttanakul

 

 February 2017

 

Pharmacological inhibition of DNA methyltransferase 1 promotes neuronal differentiation from rodent and human nasal olfactory stem/progenitor cell cultures

International Journal of Developmental Neuroscience, Available online 1 February 2017, Pages

I. Franco, L. Ortiz-López, B. Roque-Ramírez, G.B. Ramírez-Rodríguez, M. Lamas

 

Antioxidative and neuroprotective activities of peanut sprout extracts against oxidative stress in SK-N-SH cells

Asian Pacific Journal of Tropical Biomedicine

Pranee Lertkaeo, Apinun Limmongkon, Metawee Srikummool, Tantip Boonsong, Wisa Supanpaiboon, Damratsamon Surangkul

To evaluate the protective effect of peanut sprout extract (PSE) against paraquat (PQ) induced SK-N-SH cells.

Three groups of cells were used in the experiment, together with a fourth, control group. One group was treated with PQ, the second group was treated with PSE, and the third group was pre-treated with PSE. The control group was untreated. Cell viability and toxicity were detected by MTT assay, cellular reactive oxygen species (ROS) was detected by Muse Cell Analyzer, quantitative RT-PCR was applied to investigate the expression of SIRT1 and α-synuclein genes, and Aβ42 was detected by western blot.

The 50% effective concentration of PQ was 0.75 mmol/L. PSE had no significant cytotoxicity at a concentration of 1.5 mg/mL. In the group of cells pre-treated with PSE, cell death was significantly inhibited. In the PQ treated group, PQ was increased in the intracellular ROS in the cells. Intracellular ROS was significantly decreased in the cells treated with PSE and also those pre-treated with PSE. PSE significantly downregulated the expression of SIRT1 and α-syn genes, and it was found that PQ significantly increased β-amyloid 42 levels whereas this action was inhibited by PSE.

PSE has neuroprotective activities against oxidative stress in SK-N-SH cells induced by PQ, suggesting that PSE is a highly promising agent in the prevention of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease

Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity

Toxicology Letters

Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Maciej Wnuk

Relatively low bioavailability of plant-derived nutraceuticals with anticancer properties may limit their usefulness for prevention and therapy of cancer. In the present study, we have screened for nutraceuticals (n = 30) that would act at low micromolar range against phenotypically distinct breast cancer cell lines, namely MCF-7 (ER+, PR+/−, HER2−), MDA-MB-231 (ER−, PR−, HER2−) and SK-BR-3 (ER−, PR−, HER2+), and diosmin, a citrus fruit flavonoid belonging to a flavone subclass, was selected. MCF-7 cell line was found to be the most sensitive to diosmin treatment. Diosmin caused G2/M cell cycle arrest, elevation in p53, p21 and p27 levels and stress-induced premature senescence when used at lower concentrations (5 and 10 μM). Diosmin (20 μM) also promoted apoptosis that was not observed in normal human mammary epithelial cells (HMEC). Diosmin stimulated oxidative and nitrosative stress, DNA damage and changes in global DNA methylation patterns. The status of p53 (wild type versus mutant) and the levels of phosphorylated ERK1/2 in a steady state, and diosmin-induced autophagy may reflect diverse response to diosmin treatment in MCF-7, MDA-MB-231 and SK-BR-3 cells, which in turn results in different cell fates. Taken together, diosmin that acts at low micromolar range against breast cancer cells may be considered as a promising candidate for anticancer therapy.

SRB1 AS A NEW REDOX TARGET OF CIGARETTE SMOKE IN HUMAN SEBOCYTES   

Free Radical Biology and Medicine

Ilaria Crivellari, Claudia Sticozzi, Giuseppe Belmonte, Ximena M. Muresan, Franco Cervellati, Alessandra Pecorelli, Carlotta Cavicchio, Emanuela Maioli, Christos C. Zouboulis, Mascia Benedusi, Carlo Cervellati, Giuseppe Valacchi

For its critical location, the skin represents the major interface between the body and the environment, therefore is one of the major biological barriers against the outdoor environmental stressors. Among the several oxidative environmental stressors, cigarette smoke (CS) has been associated with the development and worsening of many skin pathologies such as acne, dermatitis, delayed wound healing, aging and skin cancer. In our previous work we have demonstrated that CS is able to affect genes involved in skin cholesterol trafficking, among which SRB1, a receptor involved in the uptake of cholesterol from HDL, seems to be very susceptible to the oxidative stress induced by CS.

In the present work we wanted to investigate the presence of SRB1 in human sebocytes and whether CS can affect cholesterol cellular uptake via the redox modulation of SRB1.

By using a co-culture system of keratinocytes/sebocytes, we found that CS exposure induced a SRB1 protein loss without affecting sebocytes viability. The decrease of SRB1 levels was a consequence of SRB1/HNE adducts formation that leads to SRB1 ubiquitination and degradation. Moreover, the CS-induced loss of SRB1 induced an alteration of sebocytes lipid content, also demonstrated by cholesterol quantification in SRB1 siRNA experiments.

In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality.

Erythro-Austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer

Phytomedicine

Jae-hyun Han, Ha Jin Jeong, Han Na Lee, Yun Ju Kwon, Heung-Mook Shin, Yura Choi, Seongmi Lee, Seung Tack Oh, Dong-il Kim, Songhee Jeon

Despite the benefits from different options of therapy for breast cancer, resistance of the disease to these therapies is rising and a novel agent is needed. Erythro-austrobailignan-6 (EA6) exhibits anti-cancer activity. However, the detailed anti-tumor mechanisms by which EA6 inhibits 4T-1 and MCF-7 cell growth have not been well studied.

In this study, we investigated the anti-proliferative and anti-tumor properties of EA6 on breast carcinoma and its accompanying mechanisms.

The cytotoxic and apoptotic effect of EA6 were measured in breast cancer cell lines of 4T-1 and MCF-7. The role of EA6 on cell proliferation and migration was examined by immunoblotting. The anti-tumor activity of EA6 was assessed in mice inoculated with 4T-1 breast cancer cells.

EA6 increased the number of Annexin V-positive apoptotic bodies and cleaved form of caspase-3 in a dose-dependent manner and phosphorylated JNK and p38 in both cells. Moreover, EA6 down-regulated cell cycle dependent proteins of CDK-4 and cyclin D1, and increased G0/G1 population in both cells. EA6-induced apoptosis is mediated by p38 MAPK and caspase-3 activation in both cells. EA6 significantly reduced HER2/EGFR/integrin β3 expression and Src phosphorylation, which was dependent on p38 MAPK activation in 4T-1 and MCF-7 cells. Furthermore, we confirmed the down-regulation of topoisomerases by EA6 treatment, but the overall effects of EA6 on topoisomerase isotype were cell type specific. Finally, EA6 (20 mg/kg/day) significantly reduced mammary tumor volume in 4T-1 bearing mice by down-regulating HER2/EGFR/integrin β3 expression in tumor tissues.

Our results offer a novel insight into the mechanism of EA6-induced apoptosis in breast cancer cells. We propose that EA6 treatment resulted in the activation of p38 MAPK and caspase-3, which eventually participated in regulating apoptosis in 4T-1 and MCF-7 cells.