HPLC Analysis of Loratadine on Purospher(R) STAR RP-18 endcapped

HPLC Analysis of Loratadine on Purospher® STAR RP-18 endcapped

Conditions

column Purospher® STAR RP-18 endcapped, 150 x 4.6 mm (1.51455.0001)
column temp. 30 °C
mobile phase [A] 2.28 g K2HPO4 in 800mL H2O, adjust pH 6.0 with H3PO4, add H2O to 1000mL; [B] methanol; (20:80, A:B)
flow rate 1 mL/min
pressure 1813 psi (125 bar)
sample Weigh appropriate amount of Loratadine to obtain 200 μg/mL (200 ppm). Dissolve with diluent.
injection 10 μL
detector 247 nm (cell: 1 μL/10 mm)

Description

Featured Industry Pharmaceutical (small molecule)
Legal Information Purospher is a registered trademark of Merck KGaA, Darmstadt, Germany
suitability application for HPLC

Materials

     
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