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Modified Silica TLC plates

Free Choice of Solvent System for Better Separations and as Pilot Method for HPLC

When separation challenges cannot be adequately resolved with standard silica, you can count on our modified silica plates to facilitate your application. Modified silica TLC plates provide additional selectivities and significantly broaden thin-layer chromatography applications. Hence, they are well suited for demanding TLC separations and as a pilot technique for HPLC. RP-2, RP-8, and RP-18 plates are based on silica gel 60 modified with aliphatic hydrocarbons. Amino-modified NH2 silica plates provide weakly basic ion-exchange characteristics with extraordinary selectivity for charged compounds. The CN and Diol modified silica plates are moderately polar and suited for both normal phase and reversed phase systems.

RP-Modified Silica Plates

RP-2, RP-8 and RP-18 are based on silica gel 60 modified with aliphatic hydrocarbons. The chain length in combination with the degree of modification defines the ability to tolerate the water of the solvent system and strongly affects retention. Migration time increases in the order RP-2, RP-8, RP-18 using the same solvent composition. The HPTLC RP-2 sorbent exhibits higher polarity and high affinity of aqueous solutions, tolerating up to 80% water, while the longer carbon chains RP-8 and R-18 can be run with up to 60% water in the solvent system.

NH2-Modified Silica Plates

The amino modified NH2 plate provides weak basic ion exchange characteristics with special selectivity for charged compounds. For many applications, it offers an alternative to PEI cellulose. Since most substances separated on modified plates are colorless, the majority of Merck KGaA, Darmstadt, Germany, modified silica plates contain the blue fluorescent, acid-stable UV indicator F254s. Samples which absorb shortwave UV at 254 nm are detected due to fluorescence quenching.

Your benefits

  • Results less dependent on atmospheric humidity
  • Allows use of aqueous solvent systems
  • RP-modified silica provides ready correlation with HPLC
  • No catalytic activity for unstable substances (e.g. oxidative degradation)

Modified silica TLC plates provide additional selectivities and significantly broaden TLC applications

RP-Modified and NH2-Modified  Silica Plates (TLC)

Product No. Description Layer Sorbent/ Coating Material/ Modification Layer Thickness/ µm Format / cm Support / Backing Pack size / Content
1.05746.0001 TLC Silica gel 60 RP-2 (silanized) Silica gel 60 RP-2 (silanized) 250 20 x 20 glass 25 plates
1.05747.0001 TLC Silica gel 60 RP-2 F254 (silanized) Silica gel 60 RP-2 F254*1 (silanized) 250 20 x 20 glass 25 plates
1.15388.0001 TLC Silica gel 60 RP-8 F254s Silica gel 60 RP-8 F254s*2 250 20 x 20 glass 25 plates
1.15424.0001 TLC Silica gel 60 RP-8 F254s Silica gel 60 RP-8 F254s*2 250 10 x 20 glass 50 plates
1.15684.0001 TLC Silica gel 60 RP-8 F254s Silica gel 60 RP-8 F254s*2 250 5 x 10 glass 25 plates
1.15389.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 250 20 x 20 glass 25 plates
1.15423.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 250 20 x 10 glass 50 plates
1.15683.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 250 5 x 20 glass 50 plates
1.15685.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 250 5 x 10 glass 25 plates
1.05559.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 200 20 x 20 aluminum 20 sheets
1.05560.0001 TLC Silica gel 60 RP-18 F254s Silica gel 60 RP-18 F254s*2 200 5 x 7.5 aluminum 20 sheets
1.05533.0001 TLC Silica gel 60 NH2 F254s Silica gel 60 NH2 F254s*2 200 20 x 20 aluminum 20 sheets

*1 F254 Fluorescent indicator
*2 F254s Fluorescent indicator, acid stable