BIOshellTM Glycan U/HPLC Columns

High resolution U/HPLC separation of Glycans, glycopeptides, polar peptides and isobaric oligosaccharides

The BIOshell™ Glycan column is a high-speed, high-performance liquid chromatography column based on a Fused-Core® particle design.

The BIOshell™ Glycan stationary phase is a highly polar ligand that possesses five hydroxyl groups tethered to the silica via novel, proprietary chemical linkage. This unique column chemistry is suitable for analysis of oligosaccharides, particularly for protein-linked glycans using the typical mobile phases for hydrophilic interactive liquid chromatography (HILIC) of oligosaccharides.


BIOshell™ Glycan Specifications
Silica: Type B (High purity silica)
Particle Platform: Superficially porous particles (SPP)
Phase Chemistry: Penta-hydroxy
Particle Size: 2.7 µm
Pore Size: 90 Å
Carbon Load: 3.2%
Surface Area: 135 m²/g
pH Range: 2 - 9
Max Temperature at Low pH: 65 °C
Max Temperature at High pH: 40 °C
Endcapped: No


The Fused-Core® particle of BIOshell™ Glycan provides a thin porous shell of high-purity silica surrounding a solid silica core. This particle design exhibits very high column efficiency due to the shallow diffusion paths in the 0.5 micron thick porous shell and the small overall particle size of 2.7 microns.

your fused core particle=

Outstanding Performance in U/HPLC
2.7 µm SPP particle with 90 Å pores.
Ideal for the separation of glycans.


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