Glucuronide Standards

Many drugs are rapidly and extensively metabolized to their glucuronide conjugates for excretion. Glucuronide reference standards are suitable for use in the manufacture of hydrolysis controls for GC/MS or LC/MS methods. They can also be used in the production of calibrators or controls in the direct analysis of glucuronides by LC-MS/MS. Direct detection of glucuronides by LC-MS/MS methods decreases sample-prep time by eliminating the hydrolysis step, which can improve accuracy of results.

Sigma-Aldrich's Cerilliant brand offers a wide selection of Certified Spiking Solutions® and Certified Reference Materials (CRMs) for native and stable-labeled glucuronides of numerous drug classes including:

● Opiates ● Anesthetics
● Steroids ● Hormones
● Benzodiazepines ● Ethanol
● Synthetic analgesics ● Phytochemicals
● Synthetic analgesics ● Cannabinoids

We provide a comprehensive Certificate of Analysis (COA) with each product that includes all analytical data on homogeneity, accuracy of concentration as compared to a calibration curve, and uncertainty and traceability information to support regulatory requirements.


Some products may not be globally available

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