Novec™ Non-Flammable Fluids for Histology Applications

Safety, Performance and Convenience You Can Trust

Traditional fluids used for freezing histology samples (including isopentane) are highly flammable and toxic. This has implications for worker safety, operating procedures, building code compliance and liability. Today’s laboratories demand a safer alternative without compromising performance. We are pleased to offer 3M™ Novec™ Engineered Fluids in convenient package sizes to meet your laboratory needs.


  • Non-flammable, low toxicity
  • High density = reduced frost
  • Inert to embedding medium
  • Inert to tissue sample
  • Less volatile = lower evaporation
  • Low global warming potential (GWP)
  • Low odor

Histology Bath Fluid Comparison

  Novec™ 7000 Novec™ 7100 Isopentane
Liquid Density (25 °C) 1.40 g/mL 1.52 g/mL 0.6 g/mL
Oral Toxicity Low toxicity Low toxicity Low toxicity
Skin Irritation Negative Negative Irritant
Eye Irritation Minimal irritation Minimal irritation Irritant
Mutagenicity Negative Negative Unknown
Flash Point (°C) None None < -51°C
Freeze Point -122.5°C -135°C -160°C
Boiling Point @ atmosphere 34°C 61°C 28°C
Flammability None None Extreme


Product Name Product Description Product No.
Novec™ 7000 Engineered Fluid
3M™ Novec™ 7000 Engineered Fluid, 1-methoxyheptafluoropropane, is a non-flammable, low global warming potential (GWP) heat transfer fluid capable of reaching -120°C. It is also useful as a direct expansion refrigerant. SHH0001-500ML
Novec™ 7100 Engineered Fluid
3M™ Novec™ 7100 Engineered Fluid, methoxy-nonafluorobutane (C4F9OCH3), is a clear, colorless and low-odor fluid intended to replace ozone-depleting substances (ODSs) and compounds with high global warming potential (GWP) in many applications. SHH0002-500ML

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